Reaction profile

The FDA adverse-event record for hyperproteinaemia

1,471 FDA adverse-event reports reference hyperproteinaemia (VeDDRA 2155). See the species, breeds, and drugs most associated with it below.

1,471
reports citing this reaction
25.2%
death-coded share
Dog
most-affected species
Trilostane
most-associated drug
Verify with FDA CVM →
1,471
Total Reports
371
Deaths
25.2%
Death Rate

Species Most Affected

Dog 1,035
Cat 408
Horse 24
Cattle 2
Ferret 2

Breeds Most Affected

Domestic Shorthair 251
Retriever - Labrador 110
Crossbred Canine/dog 95
Terrier - Yorkshire 47
Shih Tzu 42
Chihuahua 40
Retriever - Golden 39
Shepherd Dog - German 34
Domestic Longhair 34
Domestic (unspecified) 33

Associated Drugs

Trilostane 109
Maropitant Citrate 98
Carprofen 97
Meloxicam 85
Afoxolaner 75
Oclacitinib Maleate 72
Milbemycin Oxime + Spinosad 70
Gabapentin 69
Cefovecin 65
Bedinvetmab 63
Fluralaner Chew Tablets 60
Velagliflozin Proline Monohydrate 58
Moxidectin 55
Ivermectin + Pyrantel As Pamoate Salt 52
Spinosad 46
Robenacoxib 45
Buprenorphine 42
Prednisone 41
Tramadol 38
Famotidine 37

Hyperproteinaemia Reaction Insights

1,471 reports name Hyperproteinaemia; 371 recorded a death outcome (25.2% of reported events, not a population-level mortality rate). VeDDRA code: 2155.

By species: Dog (1,035 reports), Cat (408 reports), Horse (24 reports). By breed: Domestic Shorthair (251), Retriever - Labrador (110), Crossbred Canine/dog (95).

Most co-reported drugs: Trilostane (109 reports), Maropitant Citrate (98 reports), Carprofen (97 reports), Meloxicam (85 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.