Reaction profile

The FDA adverse-event record for unpalatable

27,321 FDA reports name unpalatable, a high-volume reaction in the CVM extract (VeDDRA 99951). Plate stamps and neighbourhood peers follow.

#13 of 2,481
by report volume (all reactions)
27,321
reports citing this reaction
0.5%
death-coded share
Unknown
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. UNPALATABLE has 27,321 reports now versus 27,143 in that prior snapshot: 178 more (0.7%).

Report change
+178
Death-coded reports
+1
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to UNPALATABLE changes

FDA AER · VeDDRA plate

Code 99951 VOL-HIGH

VOL-HIGH · DEATH-RARE · TOP-DECILE · NEAR-PEER · SPECIES-UNKNOWN · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-HIGH 27,321 reports
  • DEATH-RARE 0.5%
  • TOP-DECILE #13/2481
  • NEAR-PEER Death
  • SPECIES-UNKNOWN Unknown · 21,377
  • DRUG-LEAD Milbemycin Oxime… · 12,144
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Death (±2,131 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around UNPALATABLE

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Death · near29452UNPALATABLE · this reaction27321Behavioural disorder… · near24337Digestive tract disor… · near22748Ataxia · near21626Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around UNPALATABLE

UNPALATABLE: low death-coded share in the FDA AER plate

Signature read: 27,321 reports place UNPALATABLE in the upper third of FDA AER volume (#13 of 2,481). Report volume is upper-third scale: 27,321 named reports in the openFDA extract. Death-coded share is lower-third: 137 of 27,321 reports (0.5% of named reports). Nearest volume peer: Death (±2,131 reports). Lead species Unknown (21,377). Lead co-reported drug Milbemycin Oxime + Spinosad (12,144).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Milbemycin Oxime + Spinosad appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Unknown 21,377
Dog 5,085
Cat 833
Cattle 7
Horse 5
Chicken 4
Other 3
Other Canids 3
Pig 2
Guinea Pig 1

Breeds Most Affected

Unknown 21,599
Dog (unknown) 491
Domestic Shorthair 422
Retriever - Labrador 413
Crossbred Canine/dog 371
Chihuahua 261
Shih Tzu 227
Retriever - Golden 198
Terrier - Yorkshire 196
Shepherd Dog - German 176

Associated Drugs

Milbemycin Oxime + Spinosad 12,144
Spinosad 4,879
Fluralaner Chew Tablets 2,833
Milbemycin Oxime + Praziquantel 1,774
Fluralaner 13.64% 12-Week Chew 1,207
Lotilaner 725
Cyclosporine 529
Ivermectin + Pyrantel 496
Afoxolaner 445
Nitenpyram 287
Pyrantel Pamoate;Sarolaner 287
Ivermectin + Pyrantel As Pamoate Salt 278
Lotilaner,Moxidectin,Praziquantel,Pyrantel Pamoate 218
Spinosad, Milbemycin 162
Milbemycin Oxime 161
Praziquantel 148
Ivermectin, Pyrantel 120
Capromorelin Tartrate 118
Sarolaner 117
Ivermectin 104

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for UNPALATABLE, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (27,321 here).

Similar death-coded share

Nearest other reactions by death-coded share (0.5% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for UNPALATABLE (#13 of 2,481 by report volume); death-coded 0.5%. PlainBreed reaction plate · report volume stamp 27,321 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →