Reaction profile

The FDA adverse-event record for unpalatable

26,934 FDA adverse-event reports reference unpalatable (VeDDRA 99951). See the species, breeds, and drugs most associated with it below.

26,934
reports citing this reaction
0.5%
death-coded share
Unknown
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
26,934
Total Reports
131
Deaths
0.5%
Death Rate

Species Most Affected

Unknown 21,129
Dog 4,978
Cat 801
Cattle 7
Horse 5
Chicken 4
Other 3
Other Canids 3
Pig 2
Guinea Pig 1

Breeds Most Affected

Unknown 21,351
Dog (unknown) 478
Retriever - Labrador 407
Domestic Shorthair 404
Crossbred Canine/dog 363
Chihuahua 259
Shih Tzu 225
Terrier - Yorkshire 194
Retriever - Golden 189
Shepherd Dog - German 173

Associated Drugs

Milbemycin Oxime + Spinosad 12,118
Spinosad 4,874
Fluralaner Chew Tablets 2,833
Milbemycin Oxime + Praziquantel 1,727
Fluralaner 13.64% 12-Week Chew 1,207
Lotilaner 681
Cyclosporine 505
Ivermectin + Pyrantel 492
Afoxolaner 429
Nitenpyram 286
Ivermectin + Pyrantel As Pamoate Salt 270
Pyrantel Pamoate;Sarolaner 232
Spinosad, Milbemycin 162
Milbemycin Oxime 153
Praziquantel 133
Ivermectin, Pyrantel 120
Capromorelin Tartrate 117
Sarolaner 114
Lotilaner,Moxidectin,Praziquantel,Pyrantel Pamoate 112
Ivermectin 104

UNPALATABLE Reaction Insights

26,934 reports name UNPALATABLE; 131 recorded a death outcome (0.5% of reported events, not a population-level mortality rate). VeDDRA code: 99951.

By species: Unknown (21,129 reports), Dog (4,978 reports), Cat (801 reports). By breed: Unknown (21,351), Dog (unknown) (478), Retriever - Labrador (407).

Most co-reported drugs: Milbemycin Oxime + Spinosad (12,118 reports), Spinosad (4,874 reports), Fluralaner Chew Tablets (2,833 reports), Milbemycin Oxime + Praziquantel (1,727 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.