Lack of efficacy (endoparasite) - heartworm
VeDDRA Code: 2430
49,836 adverse event reports referencing this reaction
49,836
Total Reports
245
Deaths
50.0%
Death Rate
Species Most Affected
Dog 49,695
Cat 132
Other Canids 4
Other 3
Wolf 2
Breeds Most Affected
Retriever - Labrador 10,134
Crossbred Canine/dog 4,990
Shepherd Dog - German 4,371
Pit Bull 2,152
Beagle 1,577
Retriever - Golden 1,269
Dog (unknown) 1,206
Shepherd Dog - Australian 1,155
Boxer (German Boxer) 1,146
Terrier (unspecified) 1,120
Associated Drugs
Ivermectin + Pyrantel As Pamoate Salt 18,221
Milbemycin Oxime + Praziquantel 9,737
Moxidectin 8,728
Milbemycin Oxime + Spinosad 7,382
Pyrantel Pamoate;Sarolaner 4,843
Melarsomine Dihydrochloride 2,244
Ivermectin + Pyrantel 2,155
Ivermectin 1,739
Milbemycin/Lufenuron Tablets 1,386
Milbemycin/Lufenuron/Pzq Chew 1,316
Milbemycin Oxime 1,181
Doxycycline 1,098
Ivermectin + Pyrantel Pamoate 789
Imidacloprid + Moxidectin 713
Afoxolaner 667
Selamectin 648
Lufenuron + Milbemycin Oxime 615
Lotilaner 516
Prednisone 442
Fluralaner 432
Source: FDA Center for Veterinary Medicine — Adverse Event Reports. Data reflects voluntary submissions and may not represent actual incidence rates.