Reaction profile

The FDA adverse-event record for death

28,470 FDA adverse-event reports reference death (VeDDRA 984). See the species, breeds, and drugs most associated with it below.

28,470
reports citing this reaction
99.5%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
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28,470
Total Reports
28,314
Deaths
99.5%
Death Rate

Species Most Affected

Dog 16,464
Cattle 5,112
Cat 4,736
Horse 480
Pig 387
Chicken 262
Sheep 156
Goat 145
Turkey 142
Fish 91

Breeds Most Affected

Dog (unknown) 3,013
Domestic Shorthair 2,031
Retriever - Labrador 1,269
Cattle (other) 1,132
Crossbred Canine/dog 1,025
Mixed (Cattle) 972
Holstein-Friesian also known as Holstein 911
Cat (unknown) 762
Chihuahua 737
Cattle (unknown) 723

Associated Drugs

Milbemycin Oxime + Spinosad 1,923
Carprofen 1,341
Maropitant Citrate 1,243
Monensin Sodium 1,148
Ivermectin + Pyrantel As Pamoate Salt 1,127
Bedinvetmab 1,072
Cefovecin 1,012
Moxidectin 994
Spinosad 960
Tulathromycin 949
Afoxolaner 921
Selamectin 626
Meloxicam 601
Ceftiofur Crystalline Free Acid 561
Isoflurane 558
Oclacitinib Maleate 550
Buprenorphine 545
Milbemycin Oxime + Praziquantel 503
Fluralaner Chew Tablets 494
Enrofloxacin 472

Death Reaction Insights

28,470 reports name Death; 28,314 recorded a death outcome (99.5% of reported events, not a population-level mortality rate). VeDDRA code: 984.

By species: Dog (16,464 reports), Cattle (5,112 reports), Cat (4,736 reports). By breed: Dog (unknown) (3,013), Domestic Shorthair (2,031), Retriever - Labrador (1,269).

Most co-reported drugs: Milbemycin Oxime + Spinosad (1,923 reports), Carprofen (1,341 reports), Maropitant Citrate (1,243 reports), Monensin Sodium (1,148 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.