Reaction profile

The FDA adverse-event record for tooth disorder

592 FDA reports name tooth disorder, a high-volume reaction in the CVM extract (VeDDRA 1846). Plate stamps and neighbourhood peers follow.

#579 of 2,481
by report volume (all reactions)
592
reports citing this reaction
11.3%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Tooth disorder has 592 reports now versus 578 in that prior snapshot: 14 more (2.4%).

Report change
+14
Death-coded reports
+1
Death-coded share
−0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Tooth disorder changes

FDA AER · VeDDRA plate

Code 1846 VOL-MID

VOL-MID · DEATH-ELEV · UPPER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 592 reports
  • DEATH-ELEV 11.3%
  • UPPER-Q #579/2481
  • PHOTO-FINISH Biting - pruritus (se…
  • SPECIES-DOG Dog · 505
  • DRUG-LEAD Milbemycin Oxime… · 185
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Biting - pruritus (see also 'Behavioural disorders') (±1 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Tooth disorder

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Neurological disorder… · near597Enlarged lymph node (… · near594INEFFECTIVE, ANTIBIOT… · near594Tooth disorder · this reacti…592Biting - pruritus (se… · near591Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Tooth disorder

What the FDA AER plate says about Tooth disorder

Signature read: 592 reports place Tooth disorder in the upper third of FDA AER volume (#579 of 2,481). Report volume is upper-third scale: 592 named reports in the openFDA extract. 67 of 592 reports were death-coded (11.3% of named reports, not a population mortality rate). Nearest volume peer: Biting - pruritus (see also 'Behavioural disorders') (±1 reports). Lead species Dog (505). Lead co-reported drug Milbemycin Oxime + Spinosad (185).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Milbemycin Oxime + Spinosad appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 505
Cat 77
Horse 4
Human 3
Rabbit 1
Other 1
Lynx 1

Breeds Most Affected

Domestic Shorthair 40
Retriever - Labrador 37
Crossbred Canine/dog 26
Chihuahua 25
Shepherd Dog - German 22
Shih Tzu 21
Terrier - Yorkshire 20
Dachshund (unspecified) 19
Dog (unknown) 15
Maltese 14

Associated Drugs

Milbemycin Oxime + Spinosad 185
Trilostane 61
Spinosad 54
Milbemycin Oxime + Praziquantel 48
Carprofen 28
Oclacitinib Maleate 22
Cyclosporine 21
Rabies Vaccine 19
Gabapentin 19
Imidacloprid + Moxidectin 19
Maropitant Citrate 19
Prednisone 18
Unspecified 17
Ivermectin 15
Cyclosporine A 15
Grapiprant 14
Bexagliflozin 14
Cefovecin Sodium 13
Meloxicam 13
Fluralaner Chew Tablets 13

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Tooth disorder, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar death-coded share

Nearest other reactions by death-coded share (11.3% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Tooth disorder (#579 of 2,481 by report volume); death-coded 11.3%. PlainBreed reaction plate · report volume stamp 592 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →