Reaction profile

The FDA adverse-event record for lack of efficacy (neoplasia, relapse)

60 FDA adverse-event reports reference lack of efficacy (neoplasia, relapse) (VeDDRA 2893). See the species, breeds, and drugs most associated with it below.

60
reports citing this reaction
13.3%
death-coded share
Dog
most-affected species
Prednisone
most-associated drug
Verify with FDA CVM →
60
Total Reports
8
Deaths
13.3%
Death Rate

Species Most Affected

Dog 60

Breeds Most Affected

Retriever - Labrador 9
Dog (unknown) 7
Boxer (German Boxer) 5
Retriever - Golden 4
Terrier - Bull - American Pit 4
Rottweiler 3
Terrier - Boston 3
Beagle 3
American Pit Bull Terrier 2
Pug 2

Associated Drugs

Prednisone 41
Tigilanol Tiglate 34
Gabapentin 32
Diphenhydramine 29
Famotidine 27
Verdinexor 22
Butorphanol Tartrate 19
Maropitant Citrate 10
Atipamezole Hydrochloride 10
Dexmedetomidine Hydrochloride 9
Dexmedetomidine 9
Butorphanol 7
Rabacfosadine 6
Propofol 6
Atipamezole 5
Unspecified 4
Tramadol 4
Prednisolone 4
Toceranib Phosphate 3
Isoflurane 3

Lack of efficacy (neoplasia, relapse) Reaction Insights

60 reports name Lack of efficacy (neoplasia, relapse); 8 recorded a death outcome (13.3% of reported events, not a population-level mortality rate). VeDDRA code: 2893.

By species: Dog (60 reports). By breed: Retriever - Labrador (9), Dog (unknown) (7), Boxer (German Boxer) (5).

Most co-reported drugs: Prednisone (41 reports), Tigilanol Tiglate (34 reports), Gabapentin (32 reports), Diphenhydramine (29 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.