Reaction profile

The FDA adverse-event record for ineffective, antibiotic

594 FDA reports name ineffective, antibiotic, a high-volume reaction in the CVM extract (VeDDRA 99083). Plate stamps and neighbourhood peers follow.

#578 of 2,481
by report volume (all reactions)
594
reports citing this reaction
26.1%
death-coded share
Cattle
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. INEFFECTIVE, ANTIBIOTIC has 594 reports now versus 594 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to INEFFECTIVE, ANTIBIOTIC changes

FDA AER · VeDDRA plate

Code 99083 VOL-MID

VOL-MID · DEATH-HOT · UPPER-Q · PHOTO-FINISH · SPECIES-CATTLE · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 594 reports
  • DEATH-HOT 26.1%
  • UPPER-Q #578/2481
  • PHOTO-FINISH Enlarged lymph node (…
  • SPECIES-CATTLE Cattle · 221
  • DRUG-LEAD Cefovecin · 192
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Enlarged lymph node (localised) (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around INEFFECTIVE, ANTIBIOTIC

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Neurological disorder… · near597Enlarged lymph node (… · near594INEFFECTIVE, ANTIBIOT… · thi…594Tooth disorder · near592Biting - pruritus (se… · near591Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around INEFFECTIVE, ANTIBIOTIC

INEFFECTIVE, ANTIBIOTIC: high death-coded share in the FDA AER plate

Signature read: 155 death-coded reports is a heavy tail count for INEFFECTIVE, ANTIBIOTIC in the CVM extract. Report volume is upper-third scale: 594 named reports in the openFDA extract. Death-coded share is upper-third: 155 of 594 reports (26.1% of named reports). Nearest volume peer: Enlarged lymph node (localised) (±0 reports). Lead species Cattle (221). Lead co-reported drug Cefovecin (192).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Cattle 221
Dog 208
Cat 142
Chicken 14
Pig 4
Horse 1
Unknown 1
Quail 1
Sheep 1
Guinea Pig 1

Breeds Most Affected

Holstein-Friesian also known as Holstein 77
Domestic Shorthair 72
Mixed (Cattle) 68
Cattle (other) 43
Cat (other) 32
Retriever - Labrador 23
Shih Tzu 16
Chihuahua 14
Chicken (unknown) 11
Retriever - Golden 10

Associated Drugs

Cefovecin 192
Ceftiofur Crystalline Free Acid 79
Oclacitinib Maleate 56
Cephapirin Sodium 51
Cefpodoxime Proxetil 50
Anti-Il31 Mab Mcs Lot #1283563 50
Amoxicillin Trihydrate;Clavulanate Potassium ( K-Clavulanate) 50
Tildipirosin Injectable 31
Infectious Bovine Rhinotracheitis Virus(Ts), Rlb 106;Bovine Parainfluenza Virus 30
Marbofloxacin 27
Bovine Parainfluenza 3, Pi3 Ebk-1/Ebht-1 Strain Al-Im;Infectious Bovine Rhinotra 21
Bovine Viral Diarrhea Virus, Type 2, Strain 53637, Lot Bvd2Mlv-D;Bovine Viral Di 21
Bovine Parainfluenza Virus 3 (Ts), Rlb103 (Nl-Bk-6), Mlv; Bovine Respiratory Syn 15
Chlortetracycline Calcium Complex (Biomass) 15
Amoxicillin (As Trihydrate); Clavulanate Potassium ( K-Clavulanate) 14
Tylosin Tartrate 14
Tylosin 14
Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str 14
Bovine Viral Diarrhea Virus, Type 2, Strain 53637, Lot Bvd2Mlv-D; Bovine Viral D 13
Selamectin 12

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for INEFFECTIVE, ANTIBIOTIC, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar death-coded share

Nearest other reactions by death-coded share (26.1% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for INEFFECTIVE, ANTIBIOTIC (#578 of 2,481 by report volume); death-coded 26.1%. PlainBreed reaction plate · death-coded report count stamp 155 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →