Reaction profile

The FDA adverse-event record for ineffective, antibiotic

594 FDA adverse-event reports reference ineffective, antibiotic (VeDDRA 99083). See the species, breeds, and drugs most associated with it below.

594
reports citing this reaction
26.1%
death-coded share
Cattle
most-affected species
Cefovecin
most-associated drug
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594
Total Reports
155
Deaths
26.1%
Death Rate

Species Most Affected

Cattle 221
Dog 208
Cat 142
Chicken 14
Pig 4
Horse 1
Unknown 1
Quail 1
Sheep 1
Guinea Pig 1

Breeds Most Affected

Holstein-Friesian also known as Holstein 77
Domestic Shorthair 72
Mixed (Cattle) 68
Cattle (other) 43
Cat (other) 32
Retriever - Labrador 23
Shih Tzu 16
Chihuahua 14
Chicken (unknown) 11
Retriever - Golden 10

Associated Drugs

Cefovecin 192
Ceftiofur Crystalline Free Acid 79
Oclacitinib Maleate 56
Cephapirin Sodium 51
Cefpodoxime Proxetil 50
Anti-Il31 Mab Mcs Lot #1283563 50
Amoxicillin Trihydrate;Clavulanate Potassium ( K-Clavulanate) 50
Tildipirosin Injectable 31
Infectious Bovine Rhinotracheitis Virus(Ts), Rlb 106;Bovine Parainfluenza Virus 30
Marbofloxacin 27
Bovine Parainfluenza 3, Pi3 Ebk-1/Ebht-1 Strain Al-Im;Infectious Bovine Rhinotra 21
Bovine Viral Diarrhea Virus, Type 2, Strain 53637, Lot Bvd2Mlv-D;Bovine Viral Di 21
Bovine Parainfluenza Virus 3 (Ts), Rlb103 (Nl-Bk-6), Mlv; Bovine Respiratory Syn 15
Chlortetracycline Calcium Complex (Biomass) 15
Amoxicillin (As Trihydrate); Clavulanate Potassium ( K-Clavulanate) 14
Tylosin Tartrate 14
Tylosin 14
Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str 14
Bovine Viral Diarrhea Virus, Type 2, Strain 53637, Lot Bvd2Mlv-D; Bovine Viral D 13
Selamectin 12

INEFFECTIVE, ANTIBIOTIC Reaction Insights

594 reports name INEFFECTIVE, ANTIBIOTIC; 155 recorded a death outcome (26.1% of reported events, not a population-level mortality rate). VeDDRA code: 99083.

By species: Cattle (221 reports), Dog (208 reports), Cat (142 reports). By breed: Holstein-Friesian also known as Holstein (77), Domestic Shorthair (72), Mixed (Cattle) (68).

Most co-reported drugs: Cefovecin (192 reports), Ceftiofur Crystalline Free Acid (79 reports), Oclacitinib Maleate (56 reports), Cephapirin Sodium (51 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.