Reaction profile

The FDA adverse-event record for growling

248 FDA adverse-event reports reference growling (VeDDRA 2755). See the species, breeds, and drugs most associated with it below.

248
reports citing this reaction
12.1%
death-coded share
Dog
most-affected species
Pyrantel Pamoate;Sarolaner
most-associated drug
Verify with FDA CVM →
248
Total Reports
30
Deaths
12.1%
Death Rate

Species Most Affected

Dog 162
Cat 86

Breeds Most Affected

Domestic Shorthair 58
Retriever - Labrador 25
Retriever - Golden 11
Dog (unknown) 9
Crossbred Canine/dog 9
Domestic Longhair 7
Terrier - Bull - American Pit 7
Shepherd Dog - Australian 6
Shepherd Dog - German 6
Domestic Mediumhair 6

Associated Drugs

Pyrantel Pamoate;Sarolaner 34
Buprenorphine 28
Fluralaner 13.64% 12-Week Chew 18
Gabapentin 14
Fluralaner Spot-On Solution 11
Afoxolaner 11
Oclacitinib Maleate 10
Bedinvetmab 10
Isoflurane 9
Cefovecin 9
Frunevetmab 9
Lotilaner 8
Rabies Vaccine 8
Ivermectin + Pyrantel As Pamoate Salt 7
Robenacoxib 7
Sarolaner 6
Propofol 6
Carprofen 6
Trilostane 5
Milbemycin Oxime + Praziquantel 5

Growling Reaction Insights

248 reports name Growling; 30 recorded a death outcome (12.1% of reported events, not a population-level mortality rate). VeDDRA code: 2755.

By species: Dog (162 reports), Cat (86 reports). By breed: Domestic Shorthair (58), Retriever - Labrador (25), Retriever - Golden (11).

Most co-reported drugs: Pyrantel Pamoate;Sarolaner (34 reports), Buprenorphine (28 reports), Fluralaner 13.64% 12-Week Chew (18 reports), Gabapentin (14 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.