Reaction profile

The FDA adverse-event record for red blood cell disorder

463 FDA reports name red blood cell disorder, a high-volume reaction in the CVM extract (VeDDRA 181). Plate stamps and neighbourhood peers follow.

#673 of 2,481
by report volume (all reactions)
463
reports citing this reaction
23.8%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Red blood cell disorder has 463 reports now versus 459 in that prior snapshot: 4 more (0.9%).

Report change
+4
Death-coded reports
+0
Death-coded share
−0.2 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Red blood cell disorder changes

FDA AER · VeDDRA plate

Code 181 VOL-LOW

VOL-LOW · DEATH-HOT · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 463 reports
  • DEATH-HOT 23.8%
  • MID-PACK #673/2481
  • PHOTO-FINISH Hepatitis
  • SPECIES-DOG Dog · 413
  • DRUG-LEAD Milbemycin Oxime… · 165
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Hepatitis (±0 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Red blood cell disorder

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Alkaline urine · near465Ear pain · near465INEFFECTIVE, WORMS · near465Hepatitis · near463Red blood cell disord… · thi…463Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Red blood cell disorder

What the FDA AER plate says about Red blood cell disorder

Signature read: 110 death-coded reports is a heavy tail count for Red blood cell disorder in the CVM extract. Report volume is upper-third scale: 463 named reports in the openFDA extract. 110 of 463 reports were death-coded (23.8% of named reports, not a population mortality rate). Nearest volume peer: Hepatitis (±0 reports). Lead species Dog (413). Lead co-reported drug Milbemycin Oxime + Spinosad (165).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Milbemycin Oxime + Spinosad appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 413
Cat 47
Horse 3

Breeds Most Affected

Domestic Shorthair 29
Crossbred Canine/dog 28
Retriever - Labrador 23
Retriever - Golden 21
Chihuahua 19
Boxer (German Boxer) 18
Dachshund (unspecified) 18
Shih Tzu 15
Terrier (unspecified) 13
Shepherd Dog - German 13

Associated Drugs

Milbemycin Oxime + Spinosad 165
Spinosad 61
Carprofen 30
Prednisone 24
Maropitant Citrate 24
Oclacitinib Maleate 23
Trilostane 18
Gabapentin 18
Fluralaner Chew Tablets 18
Meloxicam 15
Rabies Vaccine 15
Doxycycline 12
Bordetella Vaccine 11
Cyclosporine 10
Moxidectin 10
Famotidine 10
Ilunocitinib 10
Metronidazole 9
Afoxolaner 9
Emodepside + Praziquantel 8

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Red blood cell disorder, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (463 here).

Similar death-coded share

Nearest other reactions by death-coded share (23.8% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Red blood cell disorder (#673 of 2,481 by report volume); death-coded 23.8%. PlainBreed reaction plate · death-coded report count stamp 110 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →