Reaction profile

The FDA adverse-event record for red blood cell disorder

452 FDA adverse-event reports reference red blood cell disorder (VeDDRA 181). See the species, breeds, and drugs most associated with it below.

452
reports citing this reaction
24.3%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
452
Total Reports
110
Deaths
24.3%
Death Rate

Species Most Affected

Dog 405
Cat 45
Horse 2

Breeds Most Affected

Domestic Shorthair 27
Crossbred Canine/dog 27
Retriever - Labrador 22
Chihuahua 19
Retriever - Golden 19
Boxer (German Boxer) 18
Dachshund (unspecified) 18
Shih Tzu 15
Terrier (unspecified) 13
Shepherd Dog - German 12

Associated Drugs

Milbemycin Oxime + Spinosad 165
Spinosad 61
Carprofen 30
Maropitant Citrate 24
Prednisone 23
Oclacitinib Maleate 21
Trilostane 18
Gabapentin 18
Fluralaner Chew Tablets 18
Rabies Vaccine 15
Meloxicam 13
Doxycycline 12
Bordetella Vaccine 11
Cyclosporine 10
Moxidectin 10
Famotidine 10
Emodepside + Praziquantel 8
Ivermectin 8
Metronidazole 8
Tramadol 8

Red blood cell disorder Reaction Insights

452 reports name Red blood cell disorder; 110 recorded a death outcome (24.3% of reported events, not a population-level mortality rate). VeDDRA code: 181.

By species: Dog (405 reports), Cat (45 reports), Horse (2 reports). By breed: Domestic Shorthair (27), Crossbred Canine/dog (27), Retriever - Labrador (22).

Most co-reported drugs: Milbemycin Oxime + Spinosad (165 reports), Spinosad (61 reports), Carprofen (30 reports), Maropitant Citrate (24 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.