Reaction profile

The FDA adverse-event record for hepatitis

444 FDA adverse-event reports reference hepatitis (VeDDRA 493). See the species, breeds, and drugs most associated with it below.

444
reports citing this reaction
34.2%
death-coded share
Dog
most-affected species
Carprofen
most-associated drug
Verify with FDA CVM →
444
Total Reports
152
Deaths
34.2%
Death Rate

Species Most Affected

Dog 372
Cat 51
Horse 10
Cattle 5
Chicken 3
Pig 1
Other Rodents 1
Turkey 1

Breeds Most Affected

Retriever - Labrador 66
Domestic Shorthair 32
Crossbred Canine/dog 30
Retriever - Golden 16
Shih Tzu 12
Spaniel - Cocker American 12
Shepherd Dog - Australian 10
Dog (unknown) 9
Terrier (unspecified) 9
Chihuahua 9

Associated Drugs

Carprofen 72
Cyclosporine A 46
Deracoxib 45
Maropitant Citrate 29
Milbemycin Oxime + Spinosad 28
Fluralaner Chew Tablets 18
Oclacitinib Maleate 17
Spinosad 15
Trilostane 15
Lufenuron + Milbemycin Oxime 14
Prednisone 14
Afoxolaner 14
Gabapentin 12
Tramadol 12
Famotidine 12
Meloxicam 11
Cefpodoxime Proxetil 11
Ivermectin + Pyrantel As Pamoate Salt 11
Moxidectin 10
Robenacoxib 10

Hepatitis Reaction Insights

444 reports name Hepatitis; 152 recorded a death outcome (34.2% of reported events, not a population-level mortality rate). VeDDRA code: 493.

By species: Dog (372 reports), Cat (51 reports), Horse (10 reports). By breed: Retriever - Labrador (66), Domestic Shorthair (32), Crossbred Canine/dog (30).

Most co-reported drugs: Carprofen (72 reports), Cyclosporine A (46 reports), Deracoxib (45 reports), Maropitant Citrate (29 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.