Reaction profile

The FDA adverse-event record for hepatitis

463 FDA reports name hepatitis, a high-volume reaction in the CVM extract (VeDDRA 493). Plate stamps and neighbourhood peers follow.

#672 of 2,481
by report volume (all reactions)
463
reports citing this reaction
34.8%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Hepatitis has 463 reports now versus 459 in that prior snapshot: 4 more (0.9%).

Report change
+4
Death-coded reports
+1
Death-coded share
−0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Hepatitis changes

FDA AER · VeDDRA plate

Code 493 VOL-LOW

VOL-LOW · DEATH-HOT · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 463 reports
  • DEATH-HOT 34.8%
  • MID-PACK #672/2481
  • PHOTO-FINISH Red blood cell disord…
  • SPECIES-DOG Dog · 385
  • DRUG-LEAD Carprofen · 74
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Red blood cell disorder (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Hepatitis

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Alkaline urine · near465Ear pain · near465INEFFECTIVE, WORMS · near465Hepatitis · this reaction463Red blood cell disord… · near463Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Hepatitis

Hepatitis: high death-coded share in the FDA AER plate

Signature read: 161 death-coded reports is a heavy tail count for Hepatitis in the CVM extract. Report volume is upper-third scale: 463 named reports in the openFDA extract. Death-coded share is upper-third: 161 of 463 reports (34.8% of named reports). Nearest volume peer: Red blood cell disorder (±0 reports). Lead species Dog (385). Lead co-reported drug Carprofen (74).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 385
Cat 57
Horse 10
Cattle 5
Chicken 3
Pig 1
Other Rodents 1
Turkey 1

Breeds Most Affected

Retriever - Labrador 70
Domestic Shorthair 35
Crossbred Canine/dog 30
Retriever - Golden 16
Spaniel - Cocker American 13
Shih Tzu 12
Dog (unknown) 10
Shepherd Dog - Australian 10
Terrier (unspecified) 9
Chihuahua 9

Associated Drugs

Carprofen 74
Cyclosporine A 46
Deracoxib 45
Maropitant Citrate 38
Milbemycin Oxime + Spinosad 28
Gabapentin 19
Oclacitinib Maleate 18
Fluralaner Chew Tablets 18
Spinosad 15
Trilostane 15
Lufenuron + Milbemycin Oxime 14
Prednisone 14
Robenacoxib 14
Buprenorphine 14
Afoxolaner 14
Ursodiol 14
Tramadol 12
Famotidine 12
Meloxicam 11
Cefovecin Sodium 11

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Hepatitis, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (463 here).

Similar death-coded share

Nearest other reactions by death-coded share (34.8% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Hepatitis (#672 of 2,481 by report volume); death-coded 34.8%. PlainBreed reaction plate · death-coded report count stamp 161 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →