Reaction profile

The FDA adverse-event record for halitosis

449 FDA adverse-event reports reference halitosis (VeDDRA 291). See the species, breeds, and drugs most associated with it below.

449
reports citing this reaction
14.9%
death-coded share
Dog
most-affected species
Imidacloprid + Moxidectin
most-associated drug
Verify with FDA CVM →
449
Total Reports
67
Deaths
14.9%
Death Rate

Species Most Affected

Dog 405
Cat 40
Human 2
Horse 1
Unknown 1

Breeds Most Affected

Retriever - Labrador 40
Crossbred Canine/dog 36
Retriever - Golden 25
Domestic Shorthair 22
Shepherd Dog - German 21
Chihuahua 18
Dachshund (unspecified) 13
Maltese 13
Terrier - Yorkshire 12
Shih Tzu 11

Associated Drugs

Imidacloprid + Moxidectin 115
Carprofen 27
Imidacloprid, Moxidectin 24
Oclacitinib Maleate 23
Milbemycin Oxime + Spinosad 22
Spinosad 20
Meloxicam 16
Fluralaner Chew Tablets 16
Trilostane 15
Afoxolaner 15
Prednisone 14
Cyclosporine A 13
Deracoxib 12
Gabapentin 12
Bedinvetmab 11
Cyclosporine 9
Imidacloprid And Moxidectin 9
Pimobendan 9
Maropitant Citrate 9
Cefovecin 8

Halitosis Reaction Insights

449 reports name Halitosis; 67 recorded a death outcome (14.9% of reported events, not a population-level mortality rate). VeDDRA code: 291.

By species: Dog (405 reports), Cat (40 reports), Human (2 reports). By breed: Retriever - Labrador (40), Crossbred Canine/dog (36), Retriever - Golden (25).

Most co-reported drugs: Imidacloprid + Moxidectin (115 reports), Carprofen (27 reports), Imidacloprid, Moxidectin (24 reports), Oclacitinib Maleate (23 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.