Reaction profile

The FDA adverse-event record for swollen muzzle

110 FDA adverse-event reports reference swollen muzzle (VeDDRA 2905). See the species, breeds, and drugs most associated with it below.

110
reports citing this reaction
0.9%
death-coded share
Dog
most-affected species
Moxidectin
most-associated drug
Verify with FDA CVM →
110
Total Reports
1
Deaths
0.9%
Death Rate

Species Most Affected

Dog 99
Horse 10
Cat 1

Breeds Most Affected

Chihuahua 10
Retriever - Golden 8
Retriever - Labrador 8
Dachshund (unspecified) 7
Shepherd Dog - German 5
Dachshund - Miniature 5
Shepherd Dog - Australian 5
Crossbred Canine/dog 4
Mountain Dog - Bernese 3
Terrier (unspecified) 3

Associated Drugs

Moxidectin 30
Pyrantel Pamoate;Sarolaner 14
Rabies Virus, Kv 10
Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str 10
Rabies Vaccine 8
Lotilaner 7
Ivermectin + Praziquantel 7
Fluralaner 13.64% 12-Week Chew 7
Oclacitinib Maleate 7
Maropitant Citrate 6
Canine Adenovirus Type 2, Strain Manhattan, 12-13-76;Canine Distemper Virus, Str 6
Prednisone 6
Bordetella Vaccine 6
Milbemycin Oxime + Praziquantel 5
Bedinvetmab 5
Bordetella Bronchiseptica 92B 012992-7 Strain Boehringer Ingelheim 5
Canine Distemper-Adenovirus Type 2-Parainfluenza-Parvovirus Vaccine, Modified Live Virus 4
Carprofen 4
Anti-Il31 Mab Mcs Lot #1283563 4
Benadryl 3

Swollen muzzle Reaction Insights

110 reports name Swollen muzzle; 1 recorded a death outcome (0.9% of reported events, not a population-level mortality rate). VeDDRA code: 2905.

By species: Dog (99 reports), Horse (10 reports), Cat (1 reports). By breed: Chihuahua (10), Retriever - Golden (8), Retriever - Labrador (8).

Most co-reported drugs: Moxidectin (30 reports), Pyrantel Pamoate;Sarolaner (14 reports), Rabies Virus, Kv (10 reports), Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str (10 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.