Reaction profile

The FDA adverse-event record for osteosarcoma

137 FDA adverse-event reports reference osteosarcoma (VeDDRA 619). See the species, breeds, and drugs most associated with it below.

137
reports citing this reaction
45.3%
death-coded share
Dog
most-affected species
Oclacitinib Maleate
most-associated drug
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137
Total Reports
62
Deaths
45.3%
Death Rate

Species Most Affected

Dog 126
Cat 10
Unknown 1

Breeds Most Affected

Retriever - Labrador 16
Rottweiler 12
Retriever - Golden 10
Dog (unknown) 9
Greyhound 8
Domestic Shorthair 6
Deutsche Dogge, Great Dane 5
Shepherd Dog - German 5
Saint Bernard Dog 5
Crossbred Canine/dog 4

Associated Drugs

Oclacitinib Maleate 30
Bedinvetmab 24
Gabapentin 17
Milbemycin Oxime + Spinosad 14
Carprofen 12
Ivermectin + Pyrantel As Pamoate Salt 9
Grapiprant 7
Polysulfated Glycosaminoglycan 6
Cyclosporine A 5
Frunevetmab 5
Spinosad 4
Deracoxib 4
Trilostane 4
Prednisone 4
Afoxolaner 4
Pyrantel Pamoate;Sarolaner 4
Adequan 4
Firocoxib 3
Tramadol 3
Fluralaner Chew Tablets 3

Osteosarcoma Reaction Insights

137 reports name Osteosarcoma; 62 recorded a death outcome (45.3% of reported events, not a population-level mortality rate). VeDDRA code: 619.

By species: Dog (126 reports), Cat (10 reports), Unknown (1 reports). By breed: Retriever - Labrador (16), Rottweiler (12), Retriever - Golden (10).

Most co-reported drugs: Oclacitinib Maleate (30 reports), Bedinvetmab (24 reports), Gabapentin (17 reports), Milbemycin Oxime + Spinosad (14 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.