Reaction profile

The FDA adverse-event record for application site weeping (see also 'skin')

141 FDA adverse-event reports reference application site weeping (see also 'skin') (VeDDRA 32). See the species, breeds, and drugs most associated with it below.

141
reports citing this reaction
0.7%
death-coded share
Cat
most-affected species
Selamectin
most-associated drug
Verify with FDA CVM →
141
Total Reports
1
Deaths
0.7%
Death Rate

Species Most Affected

Cat 113
Dog 27
Horse 1

Breeds Most Affected

Domestic Shorthair 78
Domestic Longhair 9
Domestic Mediumhair 8
Maine Coon 5
Cat (other) 4
Mixed (Dog) 3
Shepherd Dog - German 3
Retriever - Labrador 2
Bengal 2
Siamese 2

Associated Drugs

Selamectin 53
Selamectin;Sarolaner 25
Imidacloprid + Moxidectin 22
Fluralaner Spot-On Solution 9
Emodepside + Praziquantel 8
Ivermectin + Pyrantel As Pamoate Salt 4
Flumethrin-Imidacloprid 4
Robenacoxib 4
Fipronil 9.8%/S-Methoprene 8.8%/ Amitraz 22.1% Spot-On 3
Fipronil 10%/S Methoprene 9% Spot On 3
Fluralaner/Moxidectin Spot-On 3
Ivermectin/Pyrantel Pamoate Chewable 272Mcg/652Mg 2
Doxycycline 2
Prescription Diet (Unspecified) 2
Cefovecin 2
Methylprednisolone Acetate 2
Dish Soap 2
Cefovecin Sodium 2
Gabapentin 2
Mirtazapine 2

Application site weeping (see also 'skin') Reaction Insights

141 reports name Application site weeping (see also 'skin'); 1 recorded a death outcome (0.7% of reported events, not a population-level mortality rate). VeDDRA code: 32.

By species: Cat (113 reports), Dog (27 reports), Horse (1 reports). By breed: Domestic Shorthair (78), Domestic Longhair (9), Domestic Mediumhair (8).

Most co-reported drugs: Selamectin (53 reports), Selamectin;Sarolaner (25 reports), Imidacloprid + Moxidectin (22 reports), Fluralaner Spot-On Solution (9 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.