Reaction profile

The FDA adverse-event record for application site excoriation

147 FDA adverse-event reports reference application site excoriation (VeDDRA 2194). See the species, breeds, and drugs most associated with it below.

147
reports citing this reaction
0.0%
death-coded share
Cat
most-affected species
Selamectin
most-associated drug
Verify with FDA CVM →
147
Total Reports
0
Deaths
0.0%
Death Rate

Species Most Affected

Cat 136
Dog 11

Breeds Most Affected

Domestic Shorthair 100
Domestic Mediumhair 14
Domestic Longhair 9
Siamese 4
Chihuahua 2
Shih Tzu 2
Maine Coon 2
Crossbred Canine/dog 1
Shepherd Dog - German 1
Spitz - German Pomeranian 1

Associated Drugs

Selamectin 46
Emodepside + Praziquantel 22
Selamectin;Sarolaner 21
Imidacloprid + Moxidectin 15
Fluralaner Spot-On Solution 13
Buprenorphine 11
Fluralaner/Moxidectin Spot-On 10
Flumethrin-Imidacloprid 7
Cefovecin Sodium 6
Rabies Vaccine 5
Cefovecin 4
Robenacoxib 4
Isoflurane 4
Maropitant Citrate 4
Methylprednisolone 3
Methylprednisolone Acetate 3
Prednisolone 3
Alfaxalone 3
Eprinomectin + Esafoxolaner + Praziquantel 3
Rabies 1Yr 2

Application site excoriation Reaction Insights

147 reports name Application site excoriation; 0 recorded a death outcome (0.0% of reported events, not a population-level mortality rate). VeDDRA code: 2194.

By species: Cat (136 reports), Dog (11 reports). By breed: Domestic Shorthair (100), Domestic Mediumhair (14), Domestic Longhair (9).

Most co-reported drugs: Selamectin (46 reports), Emodepside + Praziquantel (22 reports), Selamectin;Sarolaner (21 reports), Imidacloprid + Moxidectin (15 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.