Reaction profile

The FDA adverse-event record for pruritic rash

146 FDA adverse-event reports reference pruritic rash (VeDDRA 1709). See the species, breeds, and drugs most associated with it below.

146
reports citing this reaction
0.7%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
146
Total Reports
1
Deaths
0.7%
Death Rate

Species Most Affected

Dog 106
Human 24
Cat 14
Horse 2

Breeds Most Affected

Unknown 25
Retriever - Labrador 16
Crossbred Canine/dog 10
Domestic Shorthair 8
Retriever - Golden 6
Chihuahua 5
Siberian Husky 4
Beagle 4
Dog (other) 4
Pit Bull 3

Associated Drugs

Milbemycin Oxime + Spinosad 19
Afoxolaner 16
Selamectin 12
Fluralaner Chew Tablets 10
Ivermectin + Pyrantel As Pamoate Salt 9
Spinosad 8
Oclacitinib Maleate 8
Imidacloprid + Moxidectin 7
Pyrantel Pamoate;Sarolaner 7
Frunevetmab 6
Fluralaner 13.64% 12-Week Chew 5
Afoxolaner 28.3 Mg Chewable Tablets 4
Bedinvetmab 4
Ivermectin 3
Carprofen 3
Phytosphingosine Hydrochloride 3
Fluralaner Spot-On Solution 3
Amoxicillin Trihydrate;Clavulanate Potassium ( K-Clavulanate) 3
Sarolaner 3
Hydroxyzine 2

Pruritic rash Reaction Insights

146 reports name Pruritic rash; 1 recorded a death outcome (0.7% of reported events, not a population-level mortality rate). VeDDRA code: 1709.

By species: Dog (106 reports), Human (24 reports), Cat (14 reports). By breed: Unknown (25), Retriever - Labrador (16), Crossbred Canine/dog (10).

Most co-reported drugs: Milbemycin Oxime + Spinosad (19 reports), Afoxolaner (16 reports), Selamectin (12 reports), Fluralaner Chew Tablets (10 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.