Reaction profile

The FDA adverse-event record for swollen lymph node

394 FDA adverse-event reports reference swollen lymph node (VeDDRA 1818). See the species, breeds, and drugs most associated with it below.

394
reports citing this reaction
23.4%
death-coded share
Dog
most-affected species
Oclacitinib Maleate
most-associated drug
Verify with FDA CVM →
394
Total Reports
92
Deaths
23.4%
Death Rate

Species Most Affected

Dog 345
Cat 39
Human 3
Cattle 3
Horse 3
Pig 1

Breeds Most Affected

Retriever - Labrador 35
Domestic Shorthair 29
Crossbred Canine/dog 22
Retriever - Golden 21
Dog (unknown) 14
Chihuahua 13
Boxer (German Boxer) 11
Collie - Border 10
Terrier - Bull - American Pit 10
Shepherd Dog - German 10

Associated Drugs

Oclacitinib Maleate 60
Milbemycin Oxime + Spinosad 42
Carprofen 37
Afoxolaner 28
Maropitant Citrate 26
Cyclosporine 16
Prednisone 15
Ivermectin + Pyrantel As Pamoate Salt 15
Tigilanol Tiglate 15
Bedinvetmab 15
Spinosad 14
Gabapentin 14
Trilostane 13
Cyclosporine A 12
Cefovecin 11
Meloxicam 10
Metronidazole 10
Moxidectin 10
Imidacloprid + Moxidectin 8
Ivermectin 8

Swollen lymph node Reaction Insights

394 reports name Swollen lymph node; 92 recorded a death outcome (23.4% of reported events, not a population-level mortality rate). VeDDRA code: 1818.

By species: Dog (345 reports), Cat (39 reports), Human (3 reports). By breed: Retriever - Labrador (35), Domestic Shorthair (29), Crossbred Canine/dog (22).

Most co-reported drugs: Oclacitinib Maleate (60 reports), Milbemycin Oxime + Spinosad (42 reports), Carprofen (37 reports), Afoxolaner (28 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.