Reaction profile

The FDA adverse-event record for prostration

115 FDA adverse-event reports reference prostration (VeDDRA 1017). See the species, breeds, and drugs most associated with it below.

115
reports citing this reaction
22.6%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
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115
Total Reports
26
Deaths
22.6%
Death Rate

Species Most Affected

Dog 95
Cattle 10
Cat 8
Other Birds 1
Sheep 1

Breeds Most Affected

Crossbred Canine/dog 12
Cattle (unknown) 9
Terrier - Yorkshire 7
Shih Tzu 7
Retriever - Golden 5
Dog (unknown) 5
Chihuahua 4
Mixed (Dog) 3
Cat (unknown) 3
Retriever - Labrador 3

Associated Drugs

Milbemycin Oxime + Spinosad 28
Afoxolaner 68 Mg Chewable Tablets 11
Afoxolaner 28.3 Mg Chewable Tablets 9
Afoxolaner 11.3 Mg Chewable Tablets 8
Gamithromycin 7
Afoxolaner 136 Mg Chewable Tablets 7
Ivermectin 10 Mg/Ml Solution For Injection 6
Ivermectin 5
Firocoxib 4
Spinosad 4
Deracoxib 3
Eprinomectin 3
Ivermectin, Pyrantel 2
Milbemycin Oxime 2
Lufenuron + Milbemycin Oxime 2
Firocoxib 57 Mg Chewable 2
Afoxolaner 2.27% Chewable Tablet (28.3 Mg) 2
Afoxolaner 2.27% Chewable Tablet (136 Mg) 2
Nitenpyram 2
Isoflurane 1

Prostration Reaction Insights

115 reports name Prostration; 26 recorded a death outcome (22.6% of reported events, not a population-level mortality rate). VeDDRA code: 1017.

By species: Dog (95 reports), Cattle (10 reports), Cat (8 reports). By breed: Crossbred Canine/dog (12), Cattle (unknown) (9), Terrier - Yorkshire (7).

Most co-reported drugs: Milbemycin Oxime + Spinosad (28 reports), Afoxolaner 68 Mg Chewable Tablets (11 reports), Afoxolaner 28.3 Mg Chewable Tablets (9 reports), Afoxolaner 11.3 Mg Chewable Tablets (8 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.