Reaction profile

The FDA adverse-event record for drooping eyelid

402 FDA reports name drooping eyelid, a high-volume reaction in the CVM extract (VeDDRA 2236). Plate stamps and neighbourhood peers follow.

#724 of 2,481
by report volume (all reactions)
402
reports citing this reaction
8.7%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Drooping eyelid has 402 reports now versus 390 in that prior snapshot: 12 more (3.1%).

Report change
+12
Death-coded reports
+0
Death-coded share
−0.3 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Drooping eyelid changes

FDA AER · VeDDRA plate

Code 2236 VOL-LOW

VOL-LOW · DEATH-PAR · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 402 reports
  • DEATH-PAR 8.7%
  • MID-PACK #724/2481
  • PHOTO-FINISH Somnolence
  • SPECIES-DOG Dog · 363
  • DRUG-LEAD Milbemycin Oxime… · 86
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Somnolence (±0 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Drooping eyelid

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Focal seizure · near404Drooping eyelid · this react…402Somnolence · near402Increased red blood c… · near401Skin warmth · near400Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Drooping eyelid

What the FDA AER plate says about Drooping eyelid

Signature read: 402 reports place Drooping eyelid in the upper third of FDA AER volume (#724 of 2,481). Report volume is upper-third scale: 402 named reports in the openFDA extract. 35 of 402 reports were death-coded (8.7% of named reports, not a population mortality rate). Nearest volume peer: Somnolence (±0 reports). Lead species Dog (363). Lead co-reported drug Milbemycin Oxime + Spinosad (86).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Milbemycin Oxime + Spinosad appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 363
Cat 35
Human 2
Cattle 1
Horse 1

Breeds Most Affected

Retriever - Labrador 65
Retriever - Golden 41
Boxer (German Boxer) 31
Domestic Shorthair 25
Crossbred Canine/dog 17
Bulldog - French 11
Spaniel - Cocker American 9
Pit Bull 8
Terrier - Bull - American Pit 7
Chihuahua 7

Associated Drugs

Milbemycin Oxime + Spinosad 86
Bedinvetmab 34
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 30
Afoxolaner 27
Oclacitinib Maleate 27
Sarolaner 18
Prednisone 17
Carprofen 17
Maropitant Citrate 16
Pyrantel Pamoate;Sarolaner 16
Fluralaner 13.64% 12-Week Chew 16
Spinosad 14
Trilostane 14
Gabapentin 14
Fluralaner Chew Tablets 13
Doxycycline 9
Moxidectin 8
Anti-Il31 Mab Mcs Lot #1283563 8
Milbemycin Oxime + Praziquantel 8
Rabies Vaccine 7

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Drooping eyelid, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (402 here).

Similar death-coded share

Nearest other reactions by death-coded share (8.7% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Drooping eyelid (#724 of 2,481 by report volume); death-coded 8.7%. PlainBreed reaction plate · report volume stamp 402 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →