Reaction profile

The FDA adverse-event record for drooping eyelid

381 FDA adverse-event reports reference drooping eyelid (VeDDRA 2236). See the species, breeds, and drugs most associated with it below.

381
reports citing this reaction
8.7%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
381
Total Reports
33
Deaths
8.7%
Death Rate

Species Most Affected

Dog 344
Cat 33
Human 2
Cattle 1
Horse 1

Breeds Most Affected

Retriever - Labrador 62
Retriever - Golden 34
Boxer (German Boxer) 31
Domestic Shorthair 23
Crossbred Canine/dog 17
Spaniel - Cocker American 9
Bulldog - French 9
Pit Bull 8
Terrier - Bull - American Pit 7
Chihuahua 7

Associated Drugs

Milbemycin Oxime + Spinosad 86
Bedinvetmab 29
Afoxolaner 27
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 27
Oclacitinib Maleate 25
Sarolaner 18
Prednisone 16
Fluralaner 13.64% 12-Week Chew 16
Spinosad 14
Maropitant Citrate 14
Pyrantel Pamoate;Sarolaner 14
Carprofen 13
Fluralaner Chew Tablets 13
Gabapentin 13
Trilostane 11
Doxycycline 9
Moxidectin 8
Rabies Vaccine 7
Cephalexin 7
Imidacloprid + Moxidectin 7

Drooping eyelid Reaction Insights

381 reports name Drooping eyelid; 33 recorded a death outcome (8.7% of reported events, not a population-level mortality rate). VeDDRA code: 2236.

By species: Dog (344 reports), Cat (33 reports), Human (2 reports). By breed: Retriever - Labrador (62), Retriever - Golden (34), Boxer (German Boxer) (31).

Most co-reported drugs: Milbemycin Oxime + Spinosad (86 reports), Bedinvetmab (29 reports), Afoxolaner (27 reports), Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride (27 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.