Reaction profile

The FDA adverse-event record for focal seizure

364 FDA adverse-event reports reference focal seizure (VeDDRA 2770). See the species, breeds, and drugs most associated with it below.

364
reports citing this reaction
9.3%
death-coded share
Dog
most-affected species
Pyrantel Pamoate;Sarolaner
most-associated drug
Verify with FDA CVM →
364
Total Reports
34
Deaths
9.3%
Death Rate

Species Most Affected

Dog 331
Cat 32
Horse 1

Breeds Most Affected

Retriever - Labrador 35
Retriever - Golden 30
Crossbred Canine/dog 26
Domestic Shorthair 22
Terrier - Yorkshire 16
Boxer (German Boxer) 14
Shepherd Dog - Australian 13
Terrier (unspecified) 10
Shepherd Dog - German 8
Collie - Border 8

Associated Drugs

Pyrantel Pamoate;Sarolaner 96
Bedinvetmab 45
Fluralaner 13.64% 12-Week Chew 43
Sarolaner 29
Carprofen 20
Afoxolaner 19
Maropitant Citrate 18
Moxidectin 17
Gabapentin 17
Oclacitinib Maleate 14
Lotilaner 10
Fluralaner 5.46% 1-Month Chew 10
Fluralaner 9
Ivermectin + Pyrantel As Pamoate Salt 9
Frunevetmab 8
Milbemycin Oxime + Spinosad 7
Anti-Il31 Mab Mcs Lot #1283563 7
Cefovecin 7
Milbemycin/Lufenuron Tablets 6
Buprenorphine 6

Focal seizure Reaction Insights

364 reports name Focal seizure; 34 recorded a death outcome (9.3% of reported events, not a population-level mortality rate). VeDDRA code: 2770.

By species: Dog (331 reports), Cat (32 reports), Horse (1 reports). By breed: Retriever - Labrador (35), Retriever - Golden (30), Crossbred Canine/dog (26).

Most co-reported drugs: Pyrantel Pamoate;Sarolaner (96 reports), Bedinvetmab (45 reports), Fluralaner 13.64% 12-Week Chew (43 reports), Sarolaner (29 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.