Reaction profile

The FDA adverse-event record for oral ulceration

395 FDA adverse-event reports reference oral ulceration (VeDDRA 301). See the species, breeds, and drugs most associated with it below.

395
reports citing this reaction
19.7%
death-coded share
Dog
most-affected species
Meloxicam
most-associated drug
Verify with FDA CVM →
395
Total Reports
78
Deaths
19.7%
Death Rate

Species Most Affected

Dog 208
Cat 105
Horse 72
Cattle 3
Donkey 3
Human 1
Sheep 1
Pig 1
Ferret 1

Breeds Most Affected

Domestic Shorthair 53
Crossbred Canine/dog 23
Quarter Horse 19
Horse (unknown) 17
Retriever - Labrador 17
Domestic (unspecified) 12
Thoroughbred 10
Cat (unknown) 9
Shepherd Dog - Australian 9
Retriever - Golden 8

Associated Drugs

Meloxicam 28
Carprofen 28
Cefovecin 25
Maropitant Citrate 23
Firocoxib 22
Ivermectin, Praziquantel 19
Gabapentin 19
Robenacoxib 17
Oclacitinib Maleate 17
Selamectin 15
Ivermectin + Praziquantel 15
Milbemycin Oxime + Spinosad 14
Ivermectin(1.55%)/Praziquantel(7.75%) Paste 14
Enrofloxacin 13
Cyclosporine A 13
Prednisone 13
Cyclosporine 11
Deracoxib 10
Buprenorphine 10
Fluralaner Chew Tablets 10

Oral ulceration Reaction Insights

395 reports name Oral ulceration; 78 recorded a death outcome (19.7% of reported events, not a population-level mortality rate). VeDDRA code: 301.

By species: Dog (208 reports), Cat (105 reports), Horse (72 reports). By breed: Domestic Shorthair (53), Crossbred Canine/dog (23), Quarter Horse (19).

Most co-reported drugs: Meloxicam (28 reports), Carprofen (28 reports), Cefovecin (25 reports), Maropitant Citrate (23 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.