Reaction profile

The FDA adverse-event record for swollen face (see also 'skin')

342 FDA adverse-event reports reference swollen face (see also 'skin') (VeDDRA 1811). See the species, breeds, and drugs most associated with it below.

342
reports citing this reaction
4.4%
death-coded share
Dog
most-affected species
Moxidectin
most-associated drug
Verify with FDA CVM →
342
Total Reports
15
Deaths
4.4%
Death Rate

Species Most Affected

Dog 285
Cat 19
Human 13
Horse 13
Cattle 9
Ferret 2
Sheep 1

Breeds Most Affected

Retriever - Labrador 27
Boxer (German Boxer) 21
Terrier - Bull - American Pit 18
Chihuahua 16
Retriever - Golden 16
Crossbred Canine/dog 15
Unknown 13
Beagle 13
Domestic Shorthair 12
Shepherd Dog - German 12

Associated Drugs

Moxidectin 112
Milbemycin Oxime + Spinosad 41
Afoxolaner 21
Maropitant Citrate 16
Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str 15
Carprofen 14
Prednisone 14
Fluralaner Chew Tablets 14
Ivermectin + Pyrantel As Pamoate Salt 13
Milbemycin Oxime + Praziquantel 12
Spinosad 11
Diphenhydramine Hcl 11
Recombinant E. Coli Bl21;Recombinant E. Coli Ecl19 9
Fluralaner 13.64% 12-Week Chew 9
Oclacitinib Maleate 8
Sarolaner 8
Rabies Virus, 8
Diphenhydramine 7
Desoxycorticosterone Pivalate 6
Anti-Il31 Mab Mcs Lot #1283563 6

Swollen face (see also 'Skin') Reaction Insights

342 reports name Swollen face (see also 'Skin'); 15 recorded a death outcome (4.4% of reported events, not a population-level mortality rate). VeDDRA code: 1811.

By species: Dog (285 reports), Cat (19 reports), Human (13 reports). By breed: Retriever - Labrador (27), Boxer (German Boxer) (21), Terrier - Bull - American Pit (18).

Most co-reported drugs: Moxidectin (112 reports), Milbemycin Oxime + Spinosad (41 reports), Afoxolaner (21 reports), Maropitant Citrate (16 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.