Reaction profile

The FDA adverse-event record for lip oedema (see also 'skin')

425 FDA reports name lip oedema (see also 'skin'), a high-volume reaction in the CVM extract (VeDDRA 1577). Plate stamps and neighbourhood peers follow.

#700 of 2,481
by report volume (all reactions)
425
reports citing this reaction
2.6%
death-coded share
Horse
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Lip oedema (see also 'Skin') has 413 reports now versus 413 in that prior snapshot: 0 the same number of (0.0%).

Report change
+0
Death-coded reports
+0
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Lip oedema (see also 'Skin') changes

FDA AER · VeDDRA plate

Code 1577 VOL-LOW

VOL-LOW · DEATH-LOW · MID-PACK · PHOTO-FINISH · SPECIES-HORSE · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 425 reports
  • DEATH-LOW 2.6%
  • MID-PACK #700/2481
  • PHOTO-FINISH Shallow breathing
  • SPECIES-HORSE Horse · 263
  • DRUG-LEAD Ivermectin, Prazi… · 199
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Shallow breathing (±0 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Lip oedema

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Dental calculus · near426Lip oedema (see also… · this…425Shallow breathing · near425Ulceration NOS · near425Decreased heart rate · near424Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Lip oedema (see also 'Skin')

Lip oedema (see also 'Skin'): low death-coded share in the FDA AER plate

Signature read: Lip oedema (see also 'Skin')'s 2.6% death-coded share is among the lowest in the openFDA reaction corpus. Report volume is upper-third scale: 425 named reports in the openFDA extract. Death-coded share is lower-third: 11 of 425 reports (2.6% of named reports). Nearest volume peer: Shallow breathing (±0 reports). Lead species Horse (263). Lead co-reported drug Ivermectin, Praziquantel (199).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Ivermectin, Praziquantel appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Horse 263
Dog 117
Human 15
Cat 13
Cattle 2
Donkey 2
Other 1

Breeds Most Affected

Horse (unknown) 89
Quarter Horse 36
Thoroughbred 36
Arab 20
Crossbred Equine/horse 19
Unknown 17
Retriever - Labrador 15
Crossbred Canine/dog 13
Mixed (Horse) 11
Horse (other) 9

Associated Drugs

Ivermectin, Praziquantel 199
Ivermectin(1.55%)/Praziquantel(7.75%) Paste 28
Moxidectin 15
Ivermectin 11
Ivermectin/Praziquantel Paste 11
Ivermectin + Praziquantel 11
Afoxolaner 9
Carprofen 8
Fluralaner Chew Tablets 7
Meloxicam 6
Milbemycin Oxime + Spinosad 6
Propofol 5
Maropitant Citrate 5
Cefovecin Sodium 4
Melarsomine Dihydrochloride 4
Imidacloprid + Moxidectin 4
Lufenuron + Milbemycin Oxime 4
Rabies Virus, Kv 4
Oclacitinib Maleate 4
Ivermectin + Pyrantel As Pamoate Salt 4

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Lip oedema (see also 'Skin'), both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (425 here).

Similar death-coded share

Nearest other reactions by death-coded share (2.6% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Lip oedema (see also 'Skin') (#700 of 2,481 by report volume); death-coded 2.6%. PlainBreed reaction plate · death-coded share stamp 2.6% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →