Reaction profile

The FDA adverse-event record for incorrect dose administered nos

1,356 FDA adverse-event reports reference incorrect dose administered nos (VeDDRA 99833). See the species, breeds, and drugs most associated with it below.

1,356
reports citing this reaction
4.1%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
1,356
Total Reports
55
Deaths
4.1%
Death Rate

Species Most Affected

Dog 1,144
Cat 193
Unknown 6
Horse 5
Cattle 4
Turkey 1
Fish 1
Cockatiel 1
Lizard 1

Breeds Most Affected

Domestic Shorthair 107
Crossbred Canine/dog 105
Chihuahua 91
Retriever - Labrador 75
Terrier - Yorkshire 62
Dog (unknown) 45
Shih Tzu 43
Retriever - Golden 43
Spitz - German Pomeranian 33
Maltese 30

Associated Drugs

Milbemycin Oxime + Spinosad 185
Spinosad 182
Genta/Momet/Clotrim Ear Oint 148
Imidacloprid + Moxidectin 100
Ivermectin + Pyrantel As Pamoate Salt 98
Nitenpyram 75
Febantel + Praziquantel + Pyrantel Pamoate 63
Selamectin 57
Orbiflox/Momet/Posaco Eardrops 53
Afoxolaner 34
Fenbendazol Granules 24
Fluralaner Chew Tablets 24
Dexmedetomidine Hydrochloride 22
Trilostane 19
Lufenuron + Milbemycin Oxime 17
Ivermectin 34Mcg, Pyrantel Pamoate 28.5Mg, Praziquantel 28.5Mg 16
Pyrantel Pamoate/Praziquantel 16
Fluralaner 13.64% 12-Week Chew 15
Milbemycin Oxime, Lufenuron 14
Ivermectin 136Mcg, Pyrantel Pamoate 114Mg, Praziquantel 114Mg 13

Incorrect dose administered NOS Reaction Insights

1,356 reports name Incorrect dose administered NOS; 55 recorded a death outcome (4.1% of reported events, not a population-level mortality rate). VeDDRA code: 99833.

By species: Dog (1,144 reports), Cat (193 reports), Unknown (6 reports). By breed: Domestic Shorthair (107), Crossbred Canine/dog (105), Chihuahua (91).

Most co-reported drugs: Milbemycin Oxime + Spinosad (185 reports), Spinosad (182 reports), Genta/Momet/Clotrim Ear Oint (148 reports), Imidacloprid + Moxidectin (100 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.