Reaction profile

The FDA adverse-event record for head shake - behavioural disorder

1,097 FDA adverse-event reports reference head shake - behavioural disorder (VeDDRA 2412). See the species, breeds, and drugs most associated with it below.

1,097
reports citing this reaction
3.7%
death-coded share
Dog
most-affected species
Imidacloprid + Moxidectin
most-associated drug
Verify with FDA CVM →
1,097
Total Reports
41
Deaths
3.7%
Death Rate

Species Most Affected

Dog 735
Cat 300
Horse 49
Cattle 10
Donkey 2
Alpaca 1

Breeds Most Affected

Domestic Shorthair 168
Retriever - Labrador 94
Dog (unknown) 53
Crossbred Canine/dog 51
Retriever - Golden 44
Cat (unknown) 43
Terrier - Yorkshire 32
Chihuahua 30
Domestic Mediumhair 24
Domestic Longhair 22

Associated Drugs

Imidacloprid + Moxidectin 103
Afoxolaner 98
Moxidectin 71
Pyrantel Pamoate;Sarolaner 70
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 56
Fluralaner Chew Tablets 53
Fluralaner Spot-On Solution 52
Sarolaner 42
Milbemycin Oxime + Spinosad 38
Fluralaner 13.64% 12-Week Chew 35
Ivermectin + Pyrantel As Pamoate Salt 32
Lotilaner 32
Milbemycin Oxime + Praziquantel 28
Florfenicol/Terbinafine Hydrochloride/Mometasone Furoate 27
Nitenpyram 26
Eprinomectin + Esafoxolaner + Praziquantel 25
Prednisone 22
Capromorelin Tartrate 22
Oclacitinib Maleate 21
Maropitant Citrate 20

Head shake - behavioural disorder Reaction Insights

1,097 reports name Head shake - behavioural disorder; 41 recorded a death outcome (3.7% of reported events, not a population-level mortality rate). VeDDRA code: 2412.

By species: Dog (735 reports), Cat (300 reports), Horse (49 reports). By breed: Domestic Shorthair (168), Retriever - Labrador (94), Dog (unknown) (53).

Most co-reported drugs: Imidacloprid + Moxidectin (103 reports), Afoxolaner (98 reports), Moxidectin (71 reports), Pyrantel Pamoate;Sarolaner (70 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.