Reaction profile

The FDA adverse-event record for numbness

125 FDA adverse-event reports reference numbness (VeDDRA 1972). Plate codes and volume neighbourhood below; species, breeds, and drugs follow.

#1287 of 2,481
by report volume (all reactions)
125
reports citing this reaction
4.0%
death-coded share
Human
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Numbness has 125 reports now versus 123 in that prior snapshot: 2 more (1.6%).

Report change
+2
Death-coded reports
+0
Death-coded share
−0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Numbness changes

FDA AER · VeDDRA plate

Code 1972 VOL-LOW

VOL-LOW · DEATH-LOW · MID-PACK · PHOTO-FINISH · SPECIES-HUMAN · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 125 reports
  • DEATH-LOW 4.0%
  • MID-PACK #1287/2481
  • PHOTO-FINISH Generalised red spot
  • SPECIES-HUMAN Human · 109
  • DRUG-LEAD Imidacloprid + Mo… · 16
  • DESK-WIDE 14 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Generalised red spot (±0 reports)

Instrument codes from this reaction’s FDA CVM adverse-event extract: volume band, death-coded share, corpus rank, photo-finish peer, lead species, lead drug, breed desk, and book completeness. Not a clinical diagnosis.

Report-volume neighbourhood around Numbness

Highest and lowest poles plus nearest volume peers, not a full 2,500-reaction corpus board reprint.

Vomiting · highest174348Extensor rigidity · near126Flatulence, bloating… · near126Generalised red spot · near125Numbness · this reaction125Heart block NOS · near124Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Numbness

Numbness: low death-coded share in the FDA AER plate

Signature read: Numbness's 4.0% death-coded share is among the lowest in the openFDA reaction corpus. Report volume sits in the middle third of the reaction corpus. Death-coded share is lower-third: 5 of 125 reports (4.0% of named reports). Nearest volume peer: Generalised red spot (±0 reports). Lead species Human (109). Lead co-reported drug Imidacloprid + Moxidectin (16).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Imidacloprid + Moxidectin appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Human 109
Dog 13
Cat 3

Breeds Most Affected

Unknown 109
Terrier - Bull - American Pit 3
Cat (unknown) 2
Shepherd Dog - German 1
Shepherd Dog - Australian 1
Collie - Border 1
Lhasa Apso 1
Sheepdog - Shetland 1
Crossbred Canine/dog 1
Ridgeback - Rhodesian 1

Associated Drugs

Imidacloprid + Moxidectin 16
Tilmicosin Phosphate 7
Selamectin 7
Milbemycin Oxime + Spinosad 6
Fluralaner Spot-On Solution 6
Moxidectin 5
Tulathromycin 5
Tilmicosin 4
Ketamine 4
Bedinvetmab 4
Spinosad 3
Maropitant Citrate 3
Anastrozole 3
Ivermectin 3
Bupivacaine Liposome 3
Cyclosporine 2
Ketamine Hydrochloride 2
Dexmedetomidine Hydrochloride 2
Emodepside + Praziquantel 2
Fenbendazol Granules 2

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Numbness, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (125 here).

Similar death-coded share

Nearest other reactions by death-coded share (4.0% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Numbness (#1287 of 2,481 by report volume); death-coded 4.0%. PlainBreed reaction plate · death-coded share stamp 4.0% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →