Reaction profile

The FDA adverse-event record for numbness

122 FDA adverse-event reports reference numbness (VeDDRA 1972). See the species, breeds, and drugs most associated with it below.

122
reports citing this reaction
4.1%
death-coded share
Human
most-affected species
Imidacloprid + Moxidectin
most-associated drug
Verify with FDA CVM →
122
Total Reports
5
Deaths
4.1%
Death Rate

Species Most Affected

Human 106
Dog 13
Cat 3

Breeds Most Affected

Unknown 106
Terrier - Bull - American Pit 3
Cat (unknown) 2
Shepherd Dog - German 1
Shepherd Dog - Australian 1
Collie - Border 1
Lhasa Apso 1
Sheepdog - Shetland 1
Crossbred Canine/dog 1
Ridgeback - Rhodesian 1

Associated Drugs

Imidacloprid + Moxidectin 16
Tilmicosin Phosphate 7
Selamectin 7
Milbemycin Oxime + Spinosad 6
Fluralaner Spot-On Solution 6
Moxidectin 5
Tulathromycin 5
Tilmicosin 4
Ketamine 4
Bedinvetmab 4
Spinosad 3
Maropitant Citrate 3
Anastrozole 3
Ivermectin 3
Cyclosporine 2
Ketamine Hydrochloride 2
Dexmedetomidine Hydrochloride 2
Emodepside + Praziquantel 2
Fenbendazol Granules 2
Nitenpyram 2

Numbness Reaction Insights

122 reports name Numbness; 5 recorded a death outcome (4.1% of reported events, not a population-level mortality rate). VeDDRA code: 1972.

By species: Human (106 reports), Dog (13 reports), Cat (3 reports). By breed: Unknown (106), Terrier - Bull - American Pit (3), Cat (unknown) (2).

Most co-reported drugs: Imidacloprid + Moxidectin (16 reports), Tilmicosin Phosphate (7 reports), Selamectin (7 reports), Milbemycin Oxime + Spinosad (6 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.