Reaction profile

The FDA adverse-event record for swelling around eye

845 FDA adverse-event reports reference swelling around eye (VeDDRA 461). See the species, breeds, and drugs most associated with it below.

845
reports citing this reaction
2.7%
death-coded share
Dog
most-affected species
Moxidectin
most-associated drug
Verify with FDA CVM →
845
Total Reports
23
Deaths
2.7%
Death Rate

Species Most Affected

Dog 727
Cat 64
Human 27
Cattle 13
Horse 11
Ferret 1
Unknown 1
Other Birds 1

Breeds Most Affected

Retriever - Labrador 75
Boxer (German Boxer) 42
Chihuahua 42
Domestic Shorthair 42
Retriever - Golden 36
Crossbred Canine/dog 32
Terrier - Bull - American Pit 32
Unknown 30
Terrier - Yorkshire 20
Shepherd Dog - Australian 20

Associated Drugs

Moxidectin 174
Milbemycin Oxime + Spinosad 62
Maropitant Citrate 49
Carprofen 34
Afoxolaner 34
Oclacitinib Maleate 34
Pyrantel Pamoate;Sarolaner 32
Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str 28
Prednisone 26
Milbemycin Oxime + Praziquantel 24
Diphenhydramine 23
Rabies Virus, 23
Fluralaner Chew Tablets 22
Diphenhydramine Hcl 21
Spinosad 20
Bordetella Bronchiseptica 92B 012992-7 Strain Boehringer Ingelheim 20
Imidacloprid + Moxidectin 18
Ivermectin + Pyrantel As Pamoate Salt 18
Selamectin 17
Rabies Virus, Kv 17

Swelling around eye Reaction Insights

845 reports name Swelling around eye; 23 recorded a death outcome (2.7% of reported events, not a population-level mortality rate). VeDDRA code: 461.

By species: Dog (727 reports), Cat (64 reports), Human (27 reports). By breed: Retriever - Labrador (75), Boxer (German Boxer) (42), Chihuahua (42).

Most co-reported drugs: Moxidectin (174 reports), Milbemycin Oxime + Spinosad (62 reports), Maropitant Citrate (49 reports), Carprofen (34 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.