Reaction profile

The FDA adverse-event record for skin disorders nos

5,102 FDA adverse-event reports reference skin disorders nos (VeDDRA 1756). See the species, breeds, and drugs most associated with it below.

5,102
reports citing this reaction
2.7%
death-coded share
Dog
most-affected species
Afoxolaner
most-associated drug
Verify with FDA CVM →
5,102
Total Reports
138
Deaths
2.7%
Death Rate

Species Most Affected

Dog 4,755
Cat 224
Cattle 55
Human 48
Horse 12
Pig 2
Goat 2
Alpaca 1
Unknown 1
Donkey 1

Breeds Most Affected

Dog (unknown) 623
Crossbred Canine/dog 466
Retriever - Labrador 370
Shih Tzu 276
Terrier - Yorkshire 217
Retriever - Golden 177
Pit Bull 151
Chihuahua 145
Shepherd Dog - German 140
Domestic Shorthair 129

Associated Drugs

Afoxolaner 1,415
Milbemycin Oxime + Spinosad 667
Oclacitinib Maleate 458
Afoxolaner 28.3 Mg Chewable Tablets 457
Afoxolaner 68 Mg Chewable Tablets 313
Afoxolaner 136 Mg Chewable Tablets 211
Afoxolaner 11.3 Mg Chewable Tablets 202
Spinosad 140
Trilostane 137
Milbemycin Oxime + Praziquantel 124
Ivermectin + Pyrantel As Pamoate Salt 113
Fipronil 10%/S Methoprene 9% Spot On 107
Selamectin 97
Carprofen 87
Prednisone 72
Anti-Il31 Mab Mcs Lot #1283563 71
Nitenpyram 63
Fluralaner Chew Tablets 61
Cefovecin 58
Sarolaner 56

Skin disorders NOS Reaction Insights

5,102 reports name Skin disorders NOS; 138 recorded a death outcome (2.7% of reported events, not a population-level mortality rate). VeDDRA code: 1756.

By species: Dog (4,755 reports), Cat (224 reports), Cattle (55 reports). By breed: Dog (unknown) (623), Crossbred Canine/dog (466), Retriever - Labrador (370).

Most co-reported drugs: Afoxolaner (1,415 reports), Milbemycin Oxime + Spinosad (667 reports), Oclacitinib Maleate (458 reports), Afoxolaner 28.3 Mg Chewable Tablets (457 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.