Reaction profile

The FDA adverse-event record for skin disorders nos

5,186 FDA reports name skin disorders nos, a high-volume reaction in the CVM extract (VeDDRA 1756). Plate stamps and neighbourhood peers follow.

#94 of 2,481
by report volume (all reactions)
5,186
reports citing this reaction
2.8%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Skin disorders NOS has 5,186 reports now versus 5,153 in that prior snapshot: 33 more (0.6%).

Report change
+33
Death-coded reports
+2
Death-coded share
+0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Skin disorders NOS changes

FDA AER · VeDDRA plate

Code 1756 VOL-HIGH

VOL-HIGH · DEATH-LOW · TOP-DECILE · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-HIGH 5,186 reports
  • DEATH-LOW 2.8%
  • TOP-DECILE #94/2481
  • PHOTO-FINISH Medication error NOS
  • SPECIES-DOG Dog · 4,823
  • DRUG-LEAD Afoxolaner · 1,417
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Medication error NOS (±69 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Skin disorders NOS

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Elevated total biliru… · near5424Disorientation · near5405Skin disorders NOS · this re…5186Medication error NOS · near5117Hiding · near4988Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Skin disorders NOS

Skin disorders NOS: low death-coded share in the FDA AER plate

Signature read: 5,186 reports place Skin disorders NOS in the upper third of FDA AER volume (#94 of 2,481). Report volume is upper-third scale: 5,186 named reports in the openFDA extract. Death-coded share is lower-third: 144 of 5,186 reports (2.8% of named reports). Nearest volume peer: Medication error NOS (±69 reports). Lead species Dog (4,823). Lead co-reported drug Afoxolaner (1,417).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Afoxolaner appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 4,823
Cat 239
Cattle 55
Human 49
Horse 12
Pig 2
Goat 2
Unknown 1
Alpaca 1
Donkey 1

Breeds Most Affected

Dog (unknown) 624
Crossbred Canine/dog 472
Retriever - Labrador 379
Shih Tzu 277
Terrier - Yorkshire 217
Retriever - Golden 178
Pit Bull 153
Chihuahua 146
Shepherd Dog - German 142
Domestic Shorthair 140

Associated Drugs

Afoxolaner 1,417
Milbemycin Oxime + Spinosad 670
Oclacitinib Maleate 468
Afoxolaner 28.3 Mg Chewable Tablets 457
Afoxolaner 68 Mg Chewable Tablets 313
Afoxolaner 136 Mg Chewable Tablets 211
Afoxolaner 11.3 Mg Chewable Tablets 202
Trilostane 143
Spinosad 140
Milbemycin Oxime + Praziquantel 130
Ivermectin + Pyrantel As Pamoate Salt 115
Fipronil 10%/S Methoprene 9% Spot On 107
Selamectin 99
Carprofen 92
Prednisone 82
Anti-Il31 Mab Mcs Lot #1283563 75
Nitenpyram 66
Fluralaner Chew Tablets 61
Sarolaner 60
Cefovecin 59

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Skin disorders NOS, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (5,186 here).

Similar death-coded share

Nearest other reactions by death-coded share (2.8% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Skin disorders NOS (#94 of 2,481 by report volume); death-coded 2.8%. PlainBreed reaction plate · report volume stamp 5,186 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →