Reaction profile

The FDA adverse-event record for muscle weakness nos

858 FDA reports name muscle weakness nos, a high-volume reaction in the CVM extract (VeDDRA 1629). Plate stamps and neighbourhood peers follow.

#440 of 2,481
by report volume (all reactions)
858
reports citing this reaction
21.4%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Muscle weakness NOS has 858 reports now versus 840 in that prior snapshot: 18 more (2.1%).

Report change
+18
Death-coded reports
+1
Death-coded share
−0.3 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Muscle weakness NOS changes

FDA AER · VeDDRA plate

Code 1629 VOL-MID

VOL-MID · DEATH-HOT · UPPER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 858 reports
  • DEATH-HOT 21.4%
  • UPPER-Q #440/2481
  • PHOTO-FINISH Conjunctivitis
  • SPECIES-DOG Dog · 735
  • DRUG-LEAD Bedinvetmab · 153
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Conjunctivitis (±1 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Muscle weakness NOS

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Heavy breathing · near863Peritonitis · near859Muscle weakness NOS · this r…858Conjunctivitis · near857Muscle wasting · near853Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Muscle weakness NOS

What the FDA AER plate says about Muscle weakness NOS

Signature read: 184 death-coded reports is a heavy tail count for Muscle weakness NOS in the CVM extract. Report volume is upper-third scale: 858 named reports in the openFDA extract. 184 of 858 reports were death-coded (21.4% of named reports, not a population mortality rate). Nearest volume peer: Conjunctivitis (±1 reports). Lead species Dog (735). Lead co-reported drug Bedinvetmab (153).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Bedinvetmab appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 735
Cat 83
Horse 18
Human 7
Cattle 5
Pig 2
Chicken 2
Unknown 1
Quail 1
Pheasant 1

Breeds Most Affected

Retriever - Labrador 97
Crossbred Canine/dog 63
Domestic Shorthair 52
Retriever - Golden 35
Chihuahua 29
Dog (unknown) 28
Shepherd Dog - German 26
Beagle 21
Shih Tzu 20
Siberian Husky 19

Associated Drugs

Bedinvetmab 153
Trilostane 115
Milbemycin Oxime + Spinosad 97
Carprofen 57
Gabapentin 51
Fluralaner Chew Tablets 38
Pyrantel Pamoate;Sarolaner 37
Spinosad 32
Prednisone 32
Oclacitinib Maleate 32
Afoxolaner 30
Grapiprant 30
Enrofloxacin 29
Maropitant Citrate 28
Sarolaner 24
Moxidectin 22
Milbemycin Oxime + Praziquantel 19
Frunevetmab 17
Galliprant 17
Ivermectin 16

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Muscle weakness NOS, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (858 here).

Similar death-coded share

Nearest other reactions by death-coded share (21.4% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Muscle weakness NOS (#440 of 2,481 by report volume); death-coded 21.4%. PlainBreed reaction plate · death-coded report count stamp 184 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →