Reaction profile

The FDA adverse-event record for muscle weakness nos

825 FDA adverse-event reports reference muscle weakness nos (VeDDRA 1629). See the species, breeds, and drugs most associated with it below.

825
reports citing this reaction
21.7%
death-coded share
Dog
most-affected species
Bedinvetmab
most-associated drug
Verify with FDA CVM →
825
Total Reports
179
Deaths
21.7%
Death Rate

Species Most Affected

Dog 710
Cat 77
Horse 16
Human 7
Cattle 5
Pig 2
Chicken 2
Unknown 1
Pheasant 1
Quail 1

Breeds Most Affected

Retriever - Labrador 94
Crossbred Canine/dog 60
Domestic Shorthair 47
Retriever - Golden 34
Chihuahua 27
Dog (unknown) 27
Shepherd Dog - German 26
Beagle 21
Shih Tzu 20
Shepherd Dog - Australian 17

Associated Drugs

Bedinvetmab 137
Trilostane 106
Milbemycin Oxime + Spinosad 97
Carprofen 54
Gabapentin 48
Fluralaner Chew Tablets 38
Pyrantel Pamoate;Sarolaner 35
Spinosad 32
Prednisone 32
Oclacitinib Maleate 32
Grapiprant 30
Enrofloxacin 29
Afoxolaner 29
Maropitant Citrate 25
Sarolaner 24
Moxidectin 21
Milbemycin Oxime + Praziquantel 19
Galliprant 17
Ivermectin 16
Doxycycline 16

Muscle weakness NOS Reaction Insights

825 reports name Muscle weakness NOS; 179 recorded a death outcome (21.7% of reported events, not a population-level mortality rate). VeDDRA code: 1629.

By species: Dog (710 reports), Cat (77 reports), Horse (16 reports). By breed: Retriever - Labrador (94), Crossbred Canine/dog (60), Domestic Shorthair (47).

Most co-reported drugs: Bedinvetmab (137 reports), Trilostane (106 reports), Milbemycin Oxime + Spinosad (97 reports), Carprofen (54 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.