Reaction profile

The FDA adverse-event record for application site dermatitis

279 FDA adverse-event reports reference application site dermatitis (VeDDRA 1934). See the species, breeds, and drugs most associated with it below.

279
reports citing this reaction
2.9%
death-coded share
Cat
most-affected species
Selamectin
most-associated drug
Verify with FDA CVM →
279
Total Reports
8
Deaths
2.9%
Death Rate

Species Most Affected

Cat 208
Dog 68
Cattle 1
Human 1
Horse 1

Breeds Most Affected

Domestic Shorthair 151
Domestic Longhair 15
Crossbred Canine/dog 9
Cat (unknown) 8
Maine Coon 7
Domestic Mediumhair 7
Mixed (Dog) 6
Retriever - Labrador 5
Pit Bull 5
Siamese 5

Associated Drugs

Selamectin 84
Imidacloprid + Moxidectin 54
Selamectin;Sarolaner 33
Emodepside + Praziquantel 26
Fluralaner Spot-On Solution 20
Flumethrin-Imidacloprid 13
Buprenorphine 12
Fluralaner/Moxidectin Spot-On 9
Chlorhexidine Gluconate + Climbazole + Phytosphingosine Salicyloyl 7
Mirtazapine 6
Prednisone 5
Cefovecin Sodium 5
Phytosphingosine Hydrochloride 5
Subcutaneous Fluids 3
Rabies Vaccine 3
Diphenhydramine 3
Famotidine 3
Ivermectin/Pyrantel Pamoate Chewable 272Mcg/652Mg 3
Enrofloxacin 3
Dexamethasone 3

Application site dermatitis Reaction Insights

279 reports name Application site dermatitis; 8 recorded a death outcome (2.9% of reported events, not a population-level mortality rate). VeDDRA code: 1934.

By species: Cat (208 reports), Dog (68 reports), Cattle (1 reports). By breed: Domestic Shorthair (151), Domestic Longhair (15), Crossbred Canine/dog (9).

Most co-reported drugs: Selamectin (84 reports), Imidacloprid + Moxidectin (54 reports), Selamectin;Sarolaner (33 reports), Emodepside + Praziquantel (26 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.