Reaction profile

The FDA adverse-event record for subdued

104 FDA adverse-event reports reference subdued (VeDDRA 2646). See the species, breeds, and drugs most associated with it below.

104
reports citing this reaction
7.7%
death-coded share
Dog
most-affected species
Carprofen
most-associated drug
Verify with FDA CVM →
104
Total Reports
8
Deaths
7.7%
Death Rate

Species Most Affected

Dog 71
Cat 31
Horse 2

Breeds Most Affected

Domestic Shorthair 21
Retriever - Labrador 13
Crossbred Canine/dog 6
Chihuahua 5
Shepherd Dog - German 4
Terrier - Yorkshire 4
Retriever - Golden 3
Thoroughbred 2
Maltese 2
Shih Tzu 2

Associated Drugs

Carprofen 12
Trilostane 11
Maropitant Citrate 11
Gabapentin 8
Fluralaner Chew Tablets 7
Buprenorphine 7
Pyrantel Pamoate;Sarolaner 6
Isoflurane 6
Ivermectin + Pyrantel As Pamoate Salt 5
Polysulfated Glycosaminoglycan 5
Selamectin;Sarolaner 5
Alfaxalone 5
Milbemycin Oxime + Praziquantel 4
Afoxolaner 4
Fluralaner 13.64% 12-Week Chew 4
Butorphanol 4
Sarolaner 3
Prednisone 3
Diphenhydramine 3
Fluoxetine 3

Subdued Reaction Insights

104 reports name Subdued; 8 recorded a death outcome (7.7% of reported events, not a population-level mortality rate). VeDDRA code: 2646.

By species: Dog (71 reports), Cat (31 reports), Horse (2 reports). By breed: Domestic Shorthair (21), Retriever - Labrador (13), Crossbred Canine/dog (6).

Most co-reported drugs: Carprofen (12 reports), Trilostane (11 reports), Maropitant Citrate (11 reports), Gabapentin (8 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.