Reaction profile

The FDA adverse-event record for keratitis

69 FDA adverse-event reports reference keratitis (VeDDRA 416). See the species, breeds, and drugs most associated with it below.

69
reports citing this reaction
10.1%
death-coded share
Dog
most-affected species
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride
most-associated drug
Verify with FDA CVM →
69
Total Reports
7
Deaths
10.1%
Death Rate

Species Most Affected

Dog 60
Cat 8
Human 1

Breeds Most Affected

Retriever - Labrador 8
Shih Tzu 7
Domestic Shorthair 5
Pug 5
Crossbred Canine/dog 4
Coton de Tuléar 4
Bulldog 3
Dog (unknown) 3
Shepherd Dog - German 2
Boxer (German Boxer) 2

Associated Drugs

Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 13
Oclacitinib Maleate 7
Spinosad 6
Enrofloxacin 6
Maropitant Citrate 6
Fluralaner Chew Tablets 5
Carprofen 5
Milbemycin Oxime + Spinosad 4
Moxidectin 4
Prednisone 4
Tobramycin Ophthalmic Drops 4
Diphenhydramine Injection 4
Meloxicam 3
Recombinant Human Insulin 3
Trilostane 3
Phytosphingosine Hcl 0.01%, Lactic Acid, Salicylic Acid, Benzoic Acid, Aloe Vera Gel Solution 3
Ophthalmic Lubricant Ointment 3
Tacrolimus Ophthamlic Solution 3
Dexamethasone/Saline Otic Drop 3
Ear Flush 3

Keratitis Reaction Insights

69 reports name Keratitis; 7 recorded a death outcome (10.1% of reported events, not a population-level mortality rate). VeDDRA code: 416.

By species: Dog (60 reports), Cat (8 reports), Human (1 reports). By breed: Retriever - Labrador (8), Shih Tzu (7), Domestic Shorthair (5).

Most co-reported drugs: Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride (13 reports), Oclacitinib Maleate (7 reports), Spinosad (6 reports), Enrofloxacin (6 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.