Reaction profile

The FDA adverse-event record for multi-organ failure nos

102 FDA adverse-event reports reference multi-organ failure nos (VeDDRA 1041). See the species, breeds, and drugs most associated with it below.

102
reports citing this reaction
90.2%
death-coded share
Dog
most-affected species
Carprofen
most-associated drug
Verify with FDA CVM →
102
Total Reports
92
Deaths
90.2%
Death Rate

Species Most Affected

Dog 88
Cat 10
Cattle 3
Horse 1

Breeds Most Affected

Retriever - Labrador 8
Dog (unknown) 7
Domestic Shorthair 5
Terrier - Yorkshire 5
Rottweiler 4
Schnauzer - Miniature 4
Crossbred Canine/dog 3
Retriever - Golden 3
Shih Tzu 3
Chihuahua 3

Associated Drugs

Carprofen 13
Milbemycin Oxime + Spinosad 11
Bedinvetmab 9
Moxidectin 7
Spinosad 6
Maropitant Citrate 6
Trilostane 5
Prednisone 5
Deracoxib 4
Gabapentin 4
Pyrantel Pamoate;Sarolaner 4
Metronidazole 3
Fluralaner Chew Tablets 3
Sarolaner 3
Cefovecin 3
Afoxolaner 3
Bordetella Vaccine 2
Enrofloxacin 2
Monensin Sodium 2
Diphenhydramine Hcl 2

Multi-organ failure NOS Reaction Insights

102 reports name Multi-organ failure NOS; 92 recorded a death outcome (90.2% of reported events, not a population-level mortality rate). VeDDRA code: 1041.

By species: Dog (88 reports), Cat (10 reports), Cattle (3 reports). By breed: Retriever - Labrador (8), Dog (unknown) (7), Domestic Shorthair (5).

Most co-reported drugs: Carprofen (13 reports), Milbemycin Oxime + Spinosad (11 reports), Bedinvetmab (9 reports), Moxidectin (7 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.