Reaction profile

The FDA adverse-event record for droopy ear

110 FDA adverse-event reports reference droopy ear (VeDDRA 355). See the species, breeds, and drugs most associated with it below.

110
reports citing this reaction
14.5%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
110
Total Reports
16
Deaths
14.5%
Death Rate

Species Most Affected

Dog 67
Cat 21
Cattle 18
Horse 2
Pig 1
Rabbit 1

Breeds Most Affected

Domestic Shorthair 16
Retriever - Labrador 8
Shepherd Dog - German 8
Cattle (other) 7
Crossbred Canine/dog 6
Aberdeen Angus 4
Dog (unknown) 4
Boxer (German Boxer) 4
Corgi (unspecified) 3
Siberian Husky 3

Associated Drugs

Milbemycin Oxime + Spinosad 15
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 12
Selamectin 7
Oclacitinib Maleate 7
Mirtazapine 7
Prednisone 6
Bedinvetmab 6
Moxidectin 5
Afoxolaner 5
Florfenicol/Terbinafine Hydrochloride/Mometasone Furoate 5
Maropitant Citrate 5
Betamethasone + Florfenicol + Terbinafine 4
Bovine Virus*5/Past M+Mh Lv/Lb 3
Genta/Momet/Clotrim Ear Oint 3
Firocoxib 3
Monensin Sodium 2
Tulathromycin 2
Albendazole 2
Prednisolone 2
Meloxicam 2

Droopy ear Reaction Insights

110 reports name Droopy ear; 16 recorded a death outcome (14.5% of reported events, not a population-level mortality rate). VeDDRA code: 355.

By species: Dog (67 reports), Cat (21 reports), Cattle (18 reports). By breed: Domestic Shorthair (16), Retriever - Labrador (8), Shepherd Dog - German (8).

Most co-reported drugs: Milbemycin Oxime + Spinosad (15 reports), Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride (12 reports), Selamectin (7 reports), Oclacitinib Maleate (7 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.