Reaction profile

The FDA adverse-event record for stroke

382 FDA reports name stroke, a high-volume reaction in the CVM extract (VeDDRA 639). Plate stamps and neighbourhood peers follow.

#754 of 2,481
by report volume (all reactions)
382
reports citing this reaction
44.8%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Stroke has 382 reports now versus 376 in that prior snapshot: 6 more (1.6%).

Report change
+6
Death-coded reports
+3
Death-coded share
+0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Stroke changes

FDA AER · VeDDRA plate

Code 639 VOL-LOW

VOL-LOW · DEATH-HOT · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 382 reports
  • DEATH-HOT 44.8%
  • MID-PACK #754/2481
  • PHOTO-FINISH Hair modification NOS
  • SPECIES-DOG Dog · 318
  • DRUG-LEAD Bedinvetmab · 57
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Hair modification NOS (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Stroke

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Disorder of red blood… · near383Hair modification NOS · near382Proprioception loss · near382Stroke · this reaction382Alopecia general · near381Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Stroke

Stroke: high death-coded share in the FDA AER plate

Signature read: 171 death-coded reports is a heavy tail count for Stroke in the CVM extract. Report volume is upper-third scale: 382 named reports in the openFDA extract. Death-coded share is upper-third: 171 of 382 reports (44.8% of named reports). Nearest volume peer: Hair modification NOS (±0 reports). Lead species Dog (318). Lead co-reported drug Bedinvetmab (57).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 318
Cat 55
Horse 5
Human 4

Breeds Most Affected

Retriever - Labrador 29
Domestic Shorthair 27
Dog (unknown) 26
Crossbred Canine/dog 15
Shih Tzu 14
Terrier - Yorkshire 12
Shepherd Dog - Australian 10
Boxer (German Boxer) 9
Shepherd Dog - German 9
Chihuahua 9

Associated Drugs

Bedinvetmab 57
Milbemycin Oxime + Spinosad 41
Carprofen 26
Afoxolaner 24
Pyrantel Pamoate;Sarolaner 24
Trilostane 22
Sarolaner 20
Oclacitinib Maleate 18
Maropitant Citrate 17
Gabapentin 17
Prednisone 14
Spinosad 13
Fluralaner 13.64% 12-Week Chew 13
Cefovecin 12
Ivermectin + Pyrantel As Pamoate Salt 12
Grapiprant 12
Frunevetmab 12
Meloxicam 10
Fluralaner Chew Tablets 10
Milbemycin Oxime + Praziquantel 10

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Stroke, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar report volume

Nearest other reactions by FDA report count (382 here).

Similar death-coded share

Nearest other reactions by death-coded share (44.8% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Stroke (#754 of 2,481 by report volume); death-coded 44.8%. PlainBreed reaction plate · death-coded report count stamp 171 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →