Reaction profile

The FDA adverse-event record for stroke

363 FDA adverse-event reports reference stroke (VeDDRA 639). See the species, breeds, and drugs most associated with it below.

363
reports citing this reaction
44.4%
death-coded share
Dog
most-affected species
Bedinvetmab
most-associated drug
Verify with FDA CVM →
363
Total Reports
161
Deaths
44.4%
Death Rate

Species Most Affected

Dog 305
Cat 49
Horse 5
Human 4

Breeds Most Affected

Retriever - Labrador 26
Domestic Shorthair 25
Dog (unknown) 24
Crossbred Canine/dog 16
Shih Tzu 13
Terrier - Yorkshire 11
Shepherd Dog - Australian 10
Shepherd Dog - German 9
Chihuahua 9
Boxer (German Boxer) 8

Associated Drugs

Bedinvetmab 49
Milbemycin Oxime + Spinosad 41
Afoxolaner 24
Trilostane 22
Carprofen 22
Sarolaner 20
Pyrantel Pamoate;Sarolaner 19
Maropitant Citrate 18
Oclacitinib Maleate 18
Gabapentin 14
Spinosad 13
Prednisone 13
Fluralaner 13.64% 12-Week Chew 13
Cefovecin 12
Ivermectin + Pyrantel As Pamoate Salt 12
Grapiprant 12
Meloxicam 10
Fluralaner Chew Tablets 10
Milbemycin Oxime + Praziquantel 10
Imidacloprid + Moxidectin 7

Stroke Reaction Insights

363 reports name Stroke; 161 recorded a death outcome (44.4% of reported events, not a population-level mortality rate). VeDDRA code: 639.

By species: Dog (305 reports), Cat (49 reports), Horse (5 reports). By breed: Retriever - Labrador (26), Domestic Shorthair (25), Dog (unknown) (24).

Most co-reported drugs: Bedinvetmab (49 reports), Milbemycin Oxime + Spinosad (41 reports), Afoxolaner (24 reports), Trilostane (22 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.