Reaction profile

The FDA adverse-event record for acute renal failure

621 FDA adverse-event reports reference acute renal failure (VeDDRA 1159). See the species, breeds, and drugs most associated with it below.

621
reports citing this reaction
44.8%
death-coded share
Dog
most-affected species
Meloxicam
most-associated drug
Verify with FDA CVM →
621
Total Reports
278
Deaths
44.8%
Death Rate

Species Most Affected

Dog 401
Cat 198
Horse 18
Human 2
Primate 1
Gerbil 1

Breeds Most Affected

Domestic Shorthair 117
Retriever - Labrador 53
Chihuahua 22
Terrier - Yorkshire 19
Crossbred Canine/dog 18
Dog (unknown) 18
Shepherd Dog - German 16
Retriever - Golden 15
Domestic Mediumhair 14
Quarter Horse 14

Associated Drugs

Meloxicam 150
Carprofen 73
Deracoxib 60
Maropitant Citrate 52
Robenacoxib 46
Gabapentin 36
Tramadol 34
Bedinvetmab 34
Isoflurane 31
Propofol 30
Oclacitinib Maleate 28
Butorphanol 25
Buprenorphine 24
Trilostane 23
Milbemycin Oxime + Spinosad 22
Grapiprant 22
Famotidine 20
Cefovecin 20
Firocoxib 20
Cefazolin 17

Acute renal failure Reaction Insights

621 reports name Acute renal failure; 278 recorded a death outcome (44.8% of reported events, not a population-level mortality rate). VeDDRA code: 1159.

By species: Dog (401 reports), Cat (198 reports), Horse (18 reports). By breed: Domestic Shorthair (117), Retriever - Labrador (53), Chihuahua (22).

Most co-reported drugs: Meloxicam (150 reports), Carprofen (73 reports), Deracoxib (60 reports), Maropitant Citrate (52 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.