Reaction profile

The FDA adverse-event record for renal degeneration

67 FDA adverse-event reports reference renal degeneration (VeDDRA 2126). See the species, breeds, and drugs most associated with it below.

67
reports citing this reaction
46.3%
death-coded share
Dog
most-affected species
Trilostane
most-associated drug
Verify with FDA CVM →
67
Total Reports
31
Deaths
46.3%
Death Rate

Species Most Affected

Dog 58
Cat 8
Mouse 1

Breeds Most Affected

Retriever - Labrador 6
Domestic Shorthair 6
Chihuahua 5
Terrier - Yorkshire 4
Maltese 3
Spitz - German Pomeranian 3
Crossbred Canine/dog 3
Coton de Tuléar 3
Retriever - Golden 2
Beagle 2

Associated Drugs

Trilostane 15
Maropitant Citrate 10
Grapiprant 10
Gabapentin 10
Bedinvetmab 9
Carprofen 8
Prednisone 6
Oclacitinib Maleate 5
Tramadol 4
Cefovecin 4
Metronidazole 4
Milbemycin Oxime + Spinosad 3
Sucralfate 3
Doxycycline 3
Rattlesnake Vaccine 3
Metoclopramide 3
Fluid Therapy 3
Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str 3
Trazodone 3
Spinosad 2

Renal degeneration Reaction Insights

67 reports name Renal degeneration; 31 recorded a death outcome (46.3% of reported events, not a population-level mortality rate). VeDDRA code: 2126.

By species: Dog (58 reports), Cat (8 reports), Mouse (1 reports). By breed: Retriever - Labrador (6), Domestic Shorthair (6), Chihuahua (5).

Most co-reported drugs: Trilostane (15 reports), Maropitant Citrate (10 reports), Grapiprant (10 reports), Gabapentin (10 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.