Reaction profile

The FDA adverse-event record for low ionized calcium (ca; hypocalcaemia, ionized)

76 FDA adverse-event reports reference low ionized calcium (ca; hypocalcaemia, ionized) (VeDDRA 2686). See the species, breeds, and drugs most associated with it below.

76
reports citing this reaction
40.8%
death-coded share
Dog
most-affected species
Maropitant Citrate
most-associated drug
Verify with FDA CVM →
76
Total Reports
31
Deaths
40.8%
Death Rate

Species Most Affected

Dog 43
Cat 30
Horse 3

Breeds Most Affected

Domestic Shorthair 18
Terrier - Yorkshire 4
Domestic Longhair 4
Domestic Mediumhair 3
Retriever - Labrador 3
Collie - Border 3
Quarter Horse 2
Chihuahua 2
Pointing Dog - German Short-haired 2
Bulldog - French 2

Associated Drugs

Maropitant Citrate 17
Buprenorphine 14
Gabapentin 11
Prednisone 7
Butorphanol 7
Carprofen 6
Divested Suanovil 50 6
Maropitant 6
Propofol 6
Bexagliflozin 6
Enrofloxacin 5
Famotidine 5
Doxycycline 5
Bedinvetmab 5
Capromorelin 4
Levothyroxine 4
Robenacoxib 4
Fluid Therapy (Unknown) 4
Isoflurane 4
Rabies Vaccine 4

Low ionized calcium (Ca; Hypocalcaemia, ionized) Reaction Insights

76 reports name Low ionized calcium (Ca; Hypocalcaemia, ionized); 31 recorded a death outcome (40.8% of reported events, not a population-level mortality rate). VeDDRA code: 2686.

By species: Dog (43 reports), Cat (30 reports), Horse (3 reports). By breed: Domestic Shorthair (18), Terrier - Yorkshire (4), Domestic Longhair (4).

Most co-reported drugs: Maropitant Citrate (17 reports), Buprenorphine (14 reports), Gabapentin (11 reports), Prednisone (7 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.