Reaction profile

The FDA adverse-event record for disorder of red blood cell nos

360 FDA adverse-event reports reference disorder of red blood cell nos (VeDDRA 1416). See the species, breeds, and drugs most associated with it below.

360
reports citing this reaction
21.4%
death-coded share
Dog
most-affected species
Milbemycin Oxime + Spinosad
most-associated drug
Verify with FDA CVM →
360
Total Reports
77
Deaths
21.4%
Death Rate

Species Most Affected

Dog 326
Cat 34

Breeds Most Affected

Crossbred Canine/dog 34
Retriever - Labrador 31
Domestic Shorthair 21
Chihuahua 12
Boxer (German Boxer) 12
Terrier - Yorkshire 12
Terrier (unspecified) 10
Shepherd Dog - German 10
Shih Tzu 9
Dachshund (unspecified) 9

Associated Drugs

Milbemycin Oxime + Spinosad 79
Carprofen 36
Trilostane 34
Fluralaner 13.64% 12-Week Chew 31
Spinosad 23
Fluralaner Chew Tablets 22
Oclacitinib Maleate 21
Maropitant Citrate 20
Moxidectin 17
Famotidine 12
Doxycycline 12
Gabapentin 12
Prednisone 11
Ivermectin 10
Afoxolaner 10
Cefovecin 9
Selamectin 9
Rabies Vaccine 8
Tramadol 8
Anti-Il31 Mab Mcs Lot #1283563 8

Disorder of red blood cell NOS Reaction Insights

360 reports name Disorder of red blood cell NOS; 77 recorded a death outcome (21.4% of reported events, not a population-level mortality rate). VeDDRA code: 1416.

By species: Dog (326 reports), Cat (34 reports). By breed: Crossbred Canine/dog (34), Retriever - Labrador (31), Domestic Shorthair (21).

Most co-reported drugs: Milbemycin Oxime + Spinosad (79 reports), Carprofen (36 reports), Trilostane (34 reports), Fluralaner 13.64% 12-Week Chew (31 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.