Reaction profile

The FDA adverse-event record for hair modification nos

375 FDA adverse-event reports reference hair modification nos (VeDDRA 1508). See the species, breeds, and drugs most associated with it below.

375
reports citing this reaction
5.3%
death-coded share
Dog
most-affected species
Imidacloprid + Moxidectin
most-associated drug
Verify with FDA CVM →
375
Total Reports
20
Deaths
5.3%
Death Rate

Species Most Affected

Dog 248
Cat 70
Cattle 38
Horse 13
Human 4
Sheep 1
Pig 1

Breeds Most Affected

Retriever - Labrador 27
Domestic Shorthair 27
Retriever - Golden 23
Crossbred Canine/dog 18
Domestic (unspecified) 18
Dog (unknown) 15
Shepherd Dog - German 9
Aberdeen Angus 8
Cattle (unknown) 8
Chihuahua 8

Associated Drugs

Imidacloprid + Moxidectin 35
Afoxolaner 27
Selamectin 26
Cyclosporine 22
Trilostane 22
Cyclosporine A 18
Prednisone 17
Oclacitinib Maleate 16
Spinosad 15
Desoxycorticosterone Pivalate 12
Milbemycin Oxime + Spinosad 12
Ivermectin + Pyrantel As Pamoate Salt 12
Pergolide Mesylate 10
Emodepside + Praziquantel 10
Carprofen 8
Eprinomectin 5% Injection 8
Nitenpyram 7
Imidacloprid, Moxidectin 6
Enrofloxacin 6
Imidacloprid And Moxidectin 6

Hair modification NOS Reaction Insights

375 reports name Hair modification NOS; 20 recorded a death outcome (5.3% of reported events, not a population-level mortality rate). VeDDRA code: 1508.

By species: Dog (248 reports), Cat (70 reports), Cattle (38 reports). By breed: Retriever - Labrador (27), Domestic Shorthair (27), Retriever - Golden (23).

Most co-reported drugs: Imidacloprid + Moxidectin (35 reports), Afoxolaner (27 reports), Selamectin (26 reports), Cyclosporine (22 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.