Reaction profile
The FDA adverse-event record for spleen and reticulo-endothelial system disorder nos
399 FDA reports name spleen and reticulo-endothelial system disorder nos, a high-volume reaction in the CVM extract (VeDDRA 182). Plate stamps and neighbourhood peers follow.
- #728 of 2,481
- by report volume (all reactions)
- 399
- reports citing this reaction
- 50.6%
- death-coded share
- Dog
- most-affected species
Release-over-release change
What changed in the latest FDA data snapshot
PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Spleen and reticulo-endothelial system disorder NOS has 399 reports now versus 398 in that prior snapshot: 1 more (0.3%).
- Report change
- +1
- Death-coded reports
- +1
- Death-coded share
- +0.1 pts
This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.
Subscribe to Spleen and reticulo-endothelial system disorder NOS changesFDA AER · VeDDRA plate
Code 182 VOL-LOW
VOL-LOW · DEATH-HOT · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL
- VOL-LOW 399 reports
- DEATH-HOT 50.6%
- MID-PACK #728/2481
- PHOTO-FINISH INEFFECTIVE, OTHER DR…
- SPECIES-DOG Dog · 361
- DRUG-LEAD Trilostane · 60
- DESK-WIDE 20 breeds
- BOOK-FULL 8/8 fields
Nearest volume peer: INEFFECTIVE, OTHER DRUG(S) (±1 reports)
Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.
High-volume neighbourhood around Spleen and reticulo-endothelial system
Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.
Spleen and reticulo-endothelial system disorder NOS: high death-coded share in the FDA AER plate
Signature read: 202 death-coded reports is a heavy tail count for Spleen and reticulo-endothelial system disorder NOS in the CVM extract. Report volume is upper-third scale: 399 named reports in the openFDA extract. Death-coded share is upper-third: 202 of 399 reports (50.6% of named reports). Nearest volume peer: INEFFECTIVE, OTHER DRUG(S) (±1 reports). Lead species Dog (361). Lead co-reported drug Trilostane (60).
Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.
Species Most Affected
Breeds Most Affected
Associated Drugs
Nationwide reactions with similar profiles
Two openFDA-derived peer sets for Spleen and reticulo-endothelial system disorder NOS, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).
Similar report volume
Nearest other reactions by FDA report count (399 here).
Similar death-coded share
Nearest other reactions by death-coded share (50.6% here), distinct from the volume row.
What to do with this reaction
- Compare Spleen and reticulo-endothelial system's report profile against similar reactions nationwide. See similar reactions
- Read how death-coded share differs from a mortality rate before drawing conclusions. Understanding adverse events
- Browse the full reaction directory to compare report counts across reaction types. All reactions
A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.
Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025
Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →