Reaction profile

The FDA adverse-event record for ineffective, other drug(s)

383 FDA adverse-event reports reference ineffective, other drug(s) (VeDDRA 99132). See the species, breeds, and drugs most associated with it below.

383
reports citing this reaction
6.3%
death-coded share
Dog
most-affected species
Polysulfated Glycosaminoglycan
most-associated drug
Verify with FDA CVM →
383
Total Reports
24
Deaths
6.3%
Death Rate

Species Most Affected

Dog 323
Cat 25
Horse 22
Cattle 5
Pig 3
Ferret 2
Rat 1
Other 1
Frog 1

Breeds Most Affected

Retriever - Labrador 37
Dog (unknown) 29
Crossbred Canine/dog 25
Chihuahua 21
Shepherd Dog - German 15
Retriever - Golden 14
Domestic Shorthair 11
Boxer (German Boxer) 11
Shih Tzu 9
Terrier (unspecified) 7

Associated Drugs

Polysulfated Glycosaminoglycan 86
Phenylpropropanolamine Hcl 51
Pimobendan 44
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 28
Prednisone 25
Carprofen 19
Desoxycortone 17
Oclacitinib Maleate 16
Estriol Tablets 16
Maropitant Citrate 14
Fluoxetine 13
Desoxycortone Pivalate 13
Gabapentin 12
Trimeprazine Tartrate;Prednisolone 9
Anti-Il31 Mab Mcs Lot #1283563 9
Ropinirole Hydrochloride 8
Afoxolaner 7
Enalapril 7
Pergolide Mesylate 7
Pyrantel Pamoate;Sarolaner 7

INEFFECTIVE, OTHER DRUG(S) Reaction Insights

383 reports name INEFFECTIVE, OTHER DRUG(S); 24 recorded a death outcome (6.3% of reported events, not a population-level mortality rate). VeDDRA code: 99132.

By species: Dog (323 reports), Cat (25 reports), Horse (22 reports). By breed: Retriever - Labrador (37), Dog (unknown) (29), Crossbred Canine/dog (25).

Most co-reported drugs: Polysulfated Glycosaminoglycan (86 reports), Phenylpropropanolamine Hcl (51 reports), Pimobendan (44 reports), Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride (28 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.