Reaction profile

The FDA adverse-event record for ineffective, other drug(s)

398 FDA reports name ineffective, other drug(s), a high-volume reaction in the CVM extract (VeDDRA 99132). Plate stamps and neighbourhood peers follow.

#729 of 2,481
by report volume (all reactions)
398
reports citing this reaction
6.0%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. INEFFECTIVE, OTHER DRUG(S) has 398 reports now versus 389 in that prior snapshot: 9 more (2.3%).

Report change
+9
Death-coded reports
+0
Death-coded share
−0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to INEFFECTIVE, OTHER DRUG(S) changes

FDA AER · VeDDRA plate

Code 99132 VOL-LOW

VOL-LOW · DEATH-PAR · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 398 reports
  • DEATH-PAR 6.0%
  • MID-PACK #729/2481
  • PHOTO-FINISH Elevated protein:crea…
  • SPECIES-DOG Dog · 338
  • DRUG-LEAD Polysulfated Glyc… · 86
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Elevated protein:creatinine ratio (±1 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around INEFFECTIVE, OTHER DRUG

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Spleen and reticulo-e… · near399INEFFECTIVE, OTHER DR… · thi…398Elevated protein:crea… · near397Polycythaemia · near397Corneal disorder NOS · near396Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around INEFFECTIVE, OTHER DRUG(S)

INEFFECTIVE, OTHER DRUG(S): low death-coded share in the FDA AER plate

Signature read: INEFFECTIVE, OTHER DRUG(S)'s 6.0% death-coded share is among the lowest in the openFDA reaction corpus. Report volume is upper-third scale: 398 named reports in the openFDA extract. Death-coded share is lower-third: 24 of 398 reports (6.0% of named reports). Nearest volume peer: Elevated protein:creatinine ratio (±1 reports). Lead species Dog (338). Lead co-reported drug Polysulfated Glycosaminoglycan (86).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Polysulfated Glycosaminoglycan appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 338
Cat 25
Horse 22
Cattle 5
Pig 3
Ferret 2
Rat 1
Other 1
Frog 1

Breeds Most Affected

Retriever - Labrador 37
Dog (unknown) 31
Crossbred Canine/dog 26
Chihuahua 22
Shepherd Dog - German 15
Retriever - Golden 14
Domestic Shorthair 11
Boxer (German Boxer) 11
Shih Tzu 10
Terrier (unspecified) 7

Associated Drugs

Polysulfated Glycosaminoglycan 86
Phenylpropropanolamine Hcl 52
Pimobendan 44
Florfenicol + Mometasone Furoate + Terbinafine Hydrochloride 29
Prednisone 27
Carprofen 20
Desoxycortone 20
Maropitant Citrate 17
Oclacitinib Maleate 16
Estriol Tablets 16
Fluoxetine 13
Desoxycortone Pivalate 13
Gabapentin 12
Ropinirole Hydrochloride 11
Trimeprazine Tartrate;Prednisolone 9
Anti-Il31 Mab Mcs Lot #1283563 9
Afoxolaner 8
Enalapril 8
Pergolide Mesylate 7
Clomipramine Hydrochloride 7

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for INEFFECTIVE, OTHER DRUG(S), both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar death-coded share

Nearest other reactions by death-coded share (6.0% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for INEFFECTIVE, OTHER DRUG(S) (#729 of 2,481 by report volume); death-coded 6.0%. PlainBreed reaction plate · death-coded share stamp 6.0% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →