Reaction profile

The FDA adverse-event record for increased red blood cell count

365 FDA adverse-event reports reference increased red blood cell count (VeDDRA 2613). See the species, breeds, and drugs most associated with it below.

365
reports citing this reaction
18.9%
death-coded share
Dog
most-affected species
Moxidectin
most-associated drug
Verify with FDA CVM →
365
Total Reports
69
Deaths
18.9%
Death Rate

Species Most Affected

Dog 318
Cat 41
Horse 4
Human 1
Cattle 1

Breeds Most Affected

Retriever - Labrador 36
Domestic Shorthair 28
Crossbred Canine/dog 23
Chihuahua 12
Terrier - Yorkshire 12
Shepherd Dog - German 11
Shih Tzu 10
Shepherd Dog - Australian 9
Retriever - Golden 9
Terrier - Bull - American Pit 8

Associated Drugs

Moxidectin 34
Afoxolaner 34
Fluralaner 13.64% 12-Week Chew 33
Ivermectin + Pyrantel As Pamoate Salt 30
Oclacitinib Maleate 26
Carprofen 26
Trilostane 23
Maropitant Citrate 22
Gabapentin 22
Fluralaner Chew Tablets 18
Pyrantel Pamoate;Sarolaner 16
Milbemycin Oxime + Praziquantel 15
Lotilaner 13
Metronidazole 13
Famotidine 12
Butorphanol 11
Rabies Vaccine 10
Anti-Il31 Mab Mcs Lot #1283563 10
Enrofloxacin 10
Bedinvetmab 10

Increased red blood cell count Reaction Insights

365 reports name Increased red blood cell count; 69 recorded a death outcome (18.9% of reported events, not a population-level mortality rate). VeDDRA code: 2613.

By species: Dog (318 reports), Cat (41 reports), Horse (4 reports). By breed: Retriever - Labrador (36), Domestic Shorthair (28), Crossbred Canine/dog (23).

Most co-reported drugs: Moxidectin (34 reports), Afoxolaner (34 reports), Fluralaner 13.64% 12-Week Chew (33 reports), Ivermectin + Pyrantel As Pamoate Salt (30 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.