Reaction profile

The FDA adverse-event record for skin warmth

400 FDA reports name skin warmth, a high-volume reaction in the CVM extract (VeDDRA 2398). Plate stamps and neighbourhood peers follow.

#727 of 2,481
by report volume (all reactions)
400
reports citing this reaction
2.8%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Skin warmth has 400 reports now versus 397 in that prior snapshot: 3 more (0.8%).

Report change
+3
Death-coded reports
+0
Death-coded share
−0.0 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Skin warmth changes

FDA AER · VeDDRA plate

Code 2398 VOL-LOW

VOL-LOW · DEATH-LOW · MID-PACK · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-LOW 400 reports
  • DEATH-LOW 2.8%
  • MID-PACK #727/2481
  • PHOTO-FINISH Increased red blood c…
  • SPECIES-DOG Dog · 293
  • DRUG-LEAD Nitenpyram · 42
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Increased red blood cell count (±1 reports)

Upper-third report volume drives the scale stamps on this plate; death-coded share and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Skin warmth

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Drooping eyelid · near402Increased red blood c… · near401Skin warmth · this reaction400Spleen and reticulo-e… · near399INEFFECTIVE, OTHER DR… · near398Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Skin warmth

Skin warmth: low death-coded share in the FDA AER plate

Signature read: Skin warmth's 2.8% death-coded share is among the lowest in the openFDA reaction corpus. Report volume is upper-third scale: 400 named reports in the openFDA extract. Death-coded share is lower-third: 11 of 400 reports (2.8% of named reports). Nearest volume peer: Increased red blood cell count (±1 reports). Lead species Dog (293). Lead co-reported drug Nitenpyram (42).

Read these counts as reporting volume, not risk: per our methodology, Lead co-reported drug Nitenpyram appears in filings alongside this reaction; that is association, not causation. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 293
Cat 74
Horse 17
Human 15
Rabbit 1

Breeds Most Affected

Domestic Shorthair 45
Chihuahua 24
Crossbred Canine/dog 20
Retriever - Labrador 16
Unknown 15
Shih Tzu 13
Pit Bull 13
Beagle 10
Domestic Longhair 9
Shepherd Dog - German 9

Associated Drugs

Nitenpyram 42
Milbemycin Oxime + Spinosad 39
Afoxolaner 35
Fluralaner Chew Tablets 31
Prednisone 18
Spinosad 14
Fluralaner Spot-On Solution 14
Selamectin 12
Cyclosporine 12
Carprofen 12
Oclacitinib Maleate 11
Ivermectin + Pyrantel As Pamoate Salt 11
Enrofloxacin 10
Sarolaner 9
Milbemycin Oxime + Praziquantel 9
Maropitant Citrate 8
Moxidectin 8
Fluralaner 13.64% 12-Week Chew 7
Cefovecin 7
Imidacloprid + Moxidectin 7

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Skin warmth, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar death-coded share

Nearest other reactions by death-coded share (2.8% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Skin warmth (#727 of 2,481 by report volume); death-coded 2.8%. PlainBreed reaction plate · death-coded share stamp 2.8% · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →