Reaction profile

The FDA adverse-event record for joint swelling

511 FDA adverse-event reports reference joint swelling (VeDDRA 568). See the species, breeds, and drugs most associated with it below.

511
reports citing this reaction
15.3%
death-coded share
Dog
most-affected species
Bedinvetmab
most-associated drug
Verify with FDA CVM →
511
Total Reports
78
Deaths
15.3%
Death Rate

Species Most Affected

Dog 349
Horse 76
Cat 46
Cattle 32
Human 4
Pig 3
Goat 1

Breeds Most Affected

Retriever - Labrador 61
Shepherd Dog - German 31
Retriever - Golden 26
Domestic Shorthair 21
Quarter Horse 19
Crossbred Canine/dog 19
Cattle (other) 18
Horse (unknown) 18
Unknown 13
Boxer (German Boxer) 12

Associated Drugs

Bedinvetmab 116
Carprofen 82
Gabapentin 56
Oclacitinib Maleate 36
Frunevetmab 35
Hyaluronate Sodium 23
Prednisone 23
Milbemycin Oxime + Spinosad 21
Enrofloxacin 19
Tramadol 18
Grapiprant 18
Tulathromycin 17
Doxycycline 17
Maropitant Citrate 17
Moxidectin 17
Afoxolaner 14
Anti-Il31 Mab Mcs Lot #1283563 14
Deracoxib 13
Triamcinolone Acetonide 13
Ceftiofur Crystalline Free Acid 12

Joint swelling Reaction Insights

511 reports name Joint swelling; 78 recorded a death outcome (15.3% of reported events, not a population-level mortality rate). VeDDRA code: 568.

By species: Dog (349 reports), Horse (76 reports), Cat (46 reports). By breed: Retriever - Labrador (61), Shepherd Dog - German (31), Retriever - Golden (26).

Most co-reported drugs: Bedinvetmab (116 reports), Carprofen (82 reports), Gabapentin (56 reports), Oclacitinib Maleate (36 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.