Reaction profile

The FDA adverse-event record for small liver

244 FDA adverse-event reports reference small liver (VeDDRA 2017). See the species, breeds, and drugs most associated with it below.

244
reports citing this reaction
21.7%
death-coded share
Dog
most-affected species
Carprofen
most-associated drug
Verify with FDA CVM →
244
Total Reports
53
Deaths
21.7%
Death Rate

Species Most Affected

Dog 230
Cat 12
Other Birds 1
Cattle 1

Breeds Most Affected

Retriever - Labrador 69
Crossbred Canine/dog 14
Shih Tzu 11
Maltese 8
Chihuahua 7
Domestic Shorthair 7
Terrier (unspecified) 5
Spaniel - Cocker American 5
Doberman Pinscher 5
Dachshund (unspecified) 5

Associated Drugs

Carprofen 67
Milbemycin Oxime + Spinosad 36
Maropitant Citrate 31
Fluralaner Chew Tablets 25
Oclacitinib Maleate 18
Moxidectin 15
Sam-E, Silybin, Vitamin E, Zinc 12
Gabapentin 12
Afoxolaner 11
Famotidine 10
Trilostane 9
Meloxicam 9
Butorphanol 8
Buprenorphine 8
Amoxicillin 7
Tramadol 7
Ivermectin + Pyrantel As Pamoate Salt 7
Dexmedetomidine Hydrochloride 6
Metronidazole 6
Ampicillin 6

Small liver Reaction Insights

244 reports name Small liver; 53 recorded a death outcome (21.7% of reported events, not a population-level mortality rate). VeDDRA code: 2017.

By species: Dog (230 reports), Cat (12 reports), Other Birds (1 reports). By breed: Retriever - Labrador (69), Crossbred Canine/dog (14), Shih Tzu (11).

Most co-reported drugs: Carprofen (67 reports), Milbemycin Oxime + Spinosad (36 reports), Maropitant Citrate (31 reports), Fluralaner Chew Tablets (25 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.