Reaction profile

The FDA adverse-event record for acidic urine

165 FDA adverse-event reports reference acidic urine (VeDDRA 1951). See the species, breeds, and drugs most associated with it below.

165
reports citing this reaction
21.8%
death-coded share
Dog
most-affected species
Trilostane
most-associated drug
Verify with FDA CVM →
165
Total Reports
36
Deaths
21.8%
Death Rate

Species Most Affected

Dog 137
Cat 28

Breeds Most Affected

Domestic Shorthair 16
Retriever - Labrador 12
Shih Tzu 9
Shepherd Dog - German 7
Crossbred Canine/dog 7
Retriever - Golden 6
Chihuahua 6
Boxer (German Boxer) 5
Maltese 5
Terrier (unspecified) 4

Associated Drugs

Trilostane 33
Bedinvetmab 23
Milbemycin Oxime + Spinosad 16
Carprofen 15
Gabapentin 15
Maropitant Citrate 10
Oclacitinib Maleate 9
Spinosad 8
Meloxicam 8
Afoxolaner 7
Bexagliflozin 7
Cefpodoxime 6
Rabies Vaccine 6
Milbemycin Oxime + Praziquantel 6
Fluralaner Chew Tablets 5
Grapiprant 5
Anti-Il31 Mab Mcs Lot #1283563 5
Levothyroxine Sodium 4
Cefovecin 4
Cyclosporine A 4

Acidic urine Reaction Insights

165 reports name Acidic urine; 36 recorded a death outcome (21.8% of reported events, not a population-level mortality rate). VeDDRA code: 1951.

By species: Dog (137 reports), Cat (28 reports). By breed: Domestic Shorthair (16), Retriever - Labrador (12), Shih Tzu (9).

Most co-reported drugs: Trilostane (33 reports), Bedinvetmab (23 reports), Milbemycin Oxime + Spinosad (16 reports), Carprofen (15 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.