Reaction profile

The FDA adverse-event record for face and neck swelling (see also 'skin')

202 FDA adverse-event reports reference face and neck swelling (see also 'skin') (VeDDRA 1462). See the species, breeds, and drugs most associated with it below.

202
reports citing this reaction
8.9%
death-coded share
Dog
most-affected species
Moxidectin
most-associated drug
Verify with FDA CVM →
202
Total Reports
18
Deaths
8.9%
Death Rate

Species Most Affected

Dog 169
Horse 15
Cattle 7
Cat 6
Human 4
Bat 1

Breeds Most Affected

Chihuahua 19
Retriever - Labrador 17
Boxer (German Boxer) 13
Crossbred Canine/dog 10
Terrier - Bull - American Pit 9
Unknown 7
Retriever - Golden 6
Pit Bull 6
Terrier - Jack Russell 6
Dog (unknown) 5

Associated Drugs

Moxidectin 46
Milbemycin Oxime + Spinosad 24
Afoxolaner 12
Rabies Virus, 11
Fluralaner Chew Tablets 8
Oclacitinib Maleate 8
Bordetella Bronchiseptica 92B 012992-7 Strain Boehringer Ingelheim 8
Ivermectin + Pyrantel As Pamoate Salt 7
Maropitant Citrate 7
Leptospira Canicola L-15 Strain C-51;Leptospira Grippotyphosa 1550 Lot 10005 Str 7
Prednisone 6
Diphenhydramine Hcl 5
Cefovecin 4
Isoflurane 4
Ceftiofur Crystalline Free Acid 4
Firocoxib 4
Anti-Il31 Mab Mcs Lot #1283563 4
Fluralaner 13.64% 12-Week Chew 4
Pyrantel Pamoate;Sarolaner 4
Carprofen 3

Face and neck swelling (see also 'Skin') Reaction Insights

202 reports name Face and neck swelling (see also 'Skin'); 18 recorded a death outcome (8.9% of reported events, not a population-level mortality rate). VeDDRA code: 1462.

By species: Dog (169 reports), Horse (15 reports), Cattle (7 reports). By breed: Chihuahua (19), Retriever - Labrador (17), Boxer (German Boxer) (13).

Most co-reported drugs: Moxidectin (46 reports), Milbemycin Oxime + Spinosad (24 reports), Afoxolaner (12 reports), Rabies Virus, (11 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.