Reaction profile

The FDA adverse-event record for shock

737 FDA adverse-event reports reference shock (VeDDRA 220). See the species, breeds, and drugs most associated with it below.

737
reports citing this reaction
43.7%
death-coded share
Dog
most-affected species
Moxidectin
most-associated drug
Verify with FDA CVM →
737
Total Reports
322
Deaths
43.7%
Death Rate

Species Most Affected

Dog 627
Cat 87
Horse 11
Cattle 8
Human 2
Sheep 1
Ferret 1

Breeds Most Affected

Retriever - Labrador 65
Crossbred Canine/dog 64
Domestic Shorthair 40
Rottweiler 26
Dachshund (unspecified) 25
Shih Tzu 22
Shepherd Dog - German 21
Chihuahua 20
Terrier - Yorkshire 20
Terrier - Bull - American Pit 19

Associated Drugs

Moxidectin 104
Carprofen 77
Maropitant Citrate 67
Milbemycin Oxime + Spinosad 57
Melarsomine Dihydrochloride 46
Deracoxib 45
Melarsomine Dihydrochloride Injection 30
Meloxicam 25
Spinosad 23
Prednisone 21
Buprenorphine 21
Gabapentin 21
Isoflurane 20
Ivermectin + Pyrantel As Pamoate Salt 20
Cefovecin 19
Famotidine 19
Dexamethasone 18
Diphenhydramine Hcl 18
Firocoxib 17
Propofol 17

Shock Reaction Insights

737 reports name Shock; 322 recorded a death outcome (43.7% of reported events, not a population-level mortality rate). VeDDRA code: 220.

By species: Dog (627 reports), Cat (87 reports), Horse (11 reports). By breed: Retriever - Labrador (65), Crossbred Canine/dog (64), Domestic Shorthair (40).

Most co-reported drugs: Moxidectin (104 reports), Carprofen (77 reports), Maropitant Citrate (67 reports), Milbemycin Oxime + Spinosad (57 reports).

Read these counts as reporting volume, not risk: per our methodology, co-reporting reflects temporal association captured in voluntary submissions, not proof that a drug caused this reaction. A widely-prescribed drug will rack up more raw co-reports at an identical true rate than a rarely-used one, so compare within similar-exposure products.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

Every figure on PlainBreed is rendered directly from FDA openFDA adverse event data, no number is typed in by an editor. This page draws directly on FDA openFDA data, no figure is typed in by an editor. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.