Reaction profile

The FDA adverse-event record for shock

757 FDA reports name shock, a high-volume reaction in the CVM extract (VeDDRA 220). Plate stamps and neighbourhood peers follow.

#484 of 2,481
by report volume (all reactions)
757
reports citing this reaction
44.4%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Shock has 757 reports now versus 750 in that prior snapshot: 7 more (0.9%).

Report change
+7
Death-coded reports
+2
Death-coded share
−0.1 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Shock changes

FDA AER · VeDDRA plate

Code 220 VOL-MID

VOL-MID · DEATH-HOT · UPPER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 757 reports
  • DEATH-HOT 44.4%
  • UPPER-Q #484/2481
  • PHOTO-FINISH General pain (see oth…
  • SPECIES-DOG Dog · 639
  • DRUG-LEAD Moxidectin · 106
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: General pain (see other SOCs for specific pain) (±1 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Shock

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Colic · near762Decreased body temper… · near760Pancreatitis NOS · near760General pain (see oth… · near758Shock · this reaction757Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Shock

Shock: high death-coded share in the FDA AER plate

Signature read: 336 death-coded reports is a heavy tail count for Shock in the CVM extract. Report volume is upper-third scale: 757 named reports in the openFDA extract. Death-coded share is upper-third: 336 of 757 reports (44.4% of named reports). Nearest volume peer: General pain (see other SOCs for specific pain) (±1 reports). Lead species Dog (639). Lead co-reported drug Moxidectin (106).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 639
Cat 94
Horse 12
Cattle 8
Human 2
Sheep 1
Ferret 1

Breeds Most Affected

Crossbred Canine/dog 65
Retriever - Labrador 65
Domestic Shorthair 42
Dachshund (unspecified) 27
Rottweiler 26
Shih Tzu 22
Shepherd Dog - German 21
Terrier - Bull - American Pit 21
Chihuahua 20
Terrier - Yorkshire 20

Associated Drugs

Moxidectin 106
Carprofen 78
Maropitant Citrate 71
Milbemycin Oxime + Spinosad 57
Melarsomine Dihydrochloride 47
Deracoxib 45
Melarsomine Dihydrochloride Injection 30
Meloxicam 25
Gabapentin 24
Spinosad 23
Buprenorphine 23
Prednisone 22
Ivermectin + Pyrantel As Pamoate Salt 21
Isoflurane 20
Cefovecin 20
Famotidine 19
Dexamethasone 18
Diphenhydramine Hcl 18
Firocoxib 17
Propofol 17

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Shock, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar death-coded share

Nearest other reactions by death-coded share (44.4% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Shock (#484 of 2,481 by report volume); death-coded 44.4%. PlainBreed reaction plate · death-coded report count stamp 336 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →