Reaction profile

The FDA adverse-event record for decreased body temperature

760 FDA reports name decreased body temperature, a high-volume reaction in the CVM extract (VeDDRA 1016). Plate stamps and neighbourhood peers follow.

#481 of 2,481
by report volume (all reactions)
760
reports citing this reaction
32.9%
death-coded share
Dog
most-affected species

Release-over-release change

What changed in the latest FDA data snapshot

PlainBreed reconstructed the prior snapshot from dated openFDA partitions through 2025 Q4, then compared it with the 2026-07-27 openFDA export. Decreased body temperature has 760 reports now versus 744 in that prior snapshot: 16 more (2.2%).

Report change
+16
Death-coded reports
+4
Death-coded share
−0.2 pts

This compares reported-event counts in two source snapshots. It does not establish a change in real-world risk, product safety, or disease incidence.

Subscribe to Decreased body temperature changes

FDA AER · VeDDRA plate

Code 1016 VOL-MID

VOL-MID · DEATH-HOT · UPPER-Q · PHOTO-FINISH · SPECIES-DOG · DRUG-LEAD · DESK-WIDE · BOOK-FULL

  • VOL-MID 760 reports
  • DEATH-HOT 32.9%
  • UPPER-Q #481/2481
  • PHOTO-FINISH Pancreatitis NOS
  • SPECIES-DOG Dog · 466
  • DRUG-LEAD Milbemycin Oxime… · 97
  • DESK-WIDE 20 breeds
  • BOOK-FULL 8/8 fields

Nearest volume peer: Pancreatitis NOS (±0 reports)

Upper-third death-coded share drives the outcome stamps on this plate; volume band, corpus rank, and co-report peers follow. Not a clinical diagnosis.

High-volume neighbourhood around Decreased body temperature

Upper-third volume poles plus nearest peers, not a full reaction corpus board reprint.

Vomiting · highest174348Colic · near762INEFFECTIVE, GASTRIC… · near762Decreased body temper… · thi…760Pancreatitis NOS · near760General pain (see oth… · near758Urinary tract neoplas… · low…10
FDA AER report volume · neighbourhood around Decreased body temperature

Decreased body temperature: high death-coded share in the FDA AER plate

Signature read: 250 death-coded reports is a heavy tail count for Decreased body temperature in the CVM extract. Report volume is upper-third scale: 760 named reports in the openFDA extract. Death-coded share is upper-third: 250 of 760 reports (32.9% of named reports). Nearest volume peer: Pancreatitis NOS (±0 reports). Lead species Dog (466). Lead co-reported drug Milbemycin Oxime + Spinosad (97).

Read these counts as reporting volume, not risk: per our methodology, A high death-coded share in FDA filings does not prove causation; co-reporting is voluntary temporal association only. Browse the full reactions index or the about page for how PlainBreed frames FDA CVM extracts.

Species Most Affected

Dog 466
Cat 270
Horse 13
Human 3
Rabbit 2
Cattle 2
Pig 1
Ferret 1
Goat 1
Sheep 1

Breeds Most Affected

Domestic Shorthair 172
Chihuahua 57
Retriever - Labrador 34
Domestic Longhair 24
Shih Tzu 20
Crossbred Canine/dog 20
Terrier - Yorkshire 17
Dachshund (unspecified) 15
Dog (unknown) 15
Cat (unknown) 15

Associated Drugs

Milbemycin Oxime + Spinosad 97
Maropitant Citrate 88
Buprenorphine 73
Isoflurane 61
Spinosad 48
Robenacoxib 45
Gabapentin 45
Moxidectin 41
Carprofen 40
Propofol 31
Enrofloxacin 29
Cefovecin 29
Rabies Vaccine 28
Butorphanol 28
Dexamethasone 25
Ketamine 25
Midazolam 25
Selamectin 24
Afoxolaner 22
Metronidazole 21

Nationwide reactions with similar profiles

Two openFDA-derived peer sets for Decreased body temperature, both floored at ≥50 reports so the neighborhoods stay in the advertised mass (the volume chart above is the unfloored photo-finish strip).

Similar death-coded share

Nearest other reactions by death-coded share (32.9% here), distinct from the volume row.

What to do with this reaction

A report does not prove a drug caused the reaction; consult a veterinarian before acting on this data.

Source: FDA Center for Veterinary Medicine openFDA Animal & Veterinary Adverse Events (CVM AER) · 2025

openFDA Animal & Veterinary Adverse Events (FDA CVM) for Decreased body temperature (#481 of 2,481 by report volume); death-coded 32.9%. PlainBreed reaction plate · death-coded report count stamp 250 · vintage 2025.

Informational only. FDA adverse-event reports are voluntary and do not prove causation; consult a veterinarian before acting on them. Verify with FDA CVM →